I-ZD-Pro-OH CAS:6404-31-5

I-ZD-Pro-OH isetyenziswa kakhulu kwi-peptide chemistry ekwakheni ii-peptides kunye nee-peptidomimetics. Njenge-N-tert-butoxycarbonyl (Boc)-provided D-proline derivative, inceda ukufakwa kwee-D-proline residues kwii-peptide chains, inika ulungelelwaniso olulodwa lwe-stereochemical olunezicelo ezinokubakho ekuphuculeni umsebenzi webhayoloji kunye nokuzinza kwe-metabolic. Iingcali zekhemistri kunye nabaphandi basebenzisa i-ZD-Pro-OH kwi-solid-phase kunye ne-solution-phase peptide synthesis ukwazisa ii-D-proline motifs, okuvumela uyilo lwezakhiwo ezintsha ze-peptide zokunxibelelana okujoliswe kuzo kunye nee-receptors zebhayoloji kunye nee-enzymes. Ukongeza kwindima yayo kwi-peptide synthesis, i-ZD-Pro-OH ibalulekile ekuphuhlisweni kwe-peptidomimetics—ii-molecules ezenzelwe ukulinganisa iipropati kunye nemisebenzi yee-peptides ezisebenzayo. Ngokubandakanya izinto ezivela kwi-ZD-Pro-OH, izazinzulu zinokuhlola ukudalwa kwe-peptidomimetics ngeeprofayili ezahlukeneyo ze-pharmacological, zivula indlela yamayeza amatsha, ii-molecular probes, kunye nezixhobo ze-biochemical ezinezicelo zonyango kunye nophando ezinokubakho. Ngaphezu koko, i-ZD-Pro-OH isebenza njengecandelo elibalulekileyo ekuvelisweni kwamayeza kunye neyeza zonyango ezisekelwe kwi-peptide. Ubunyulu bayo obuphezulu kunye nokuthembeka kwayo kwenza ukuba ibe yinto ebalulekileyo ekuvelisweni kwee-peptides kunye ne-peptidomimetics ezenziwe ngokwezifiso kwizifundo zangaphambi kweklinikhi nezeklinikhi, zinika abaphandi ukuguquguquka kokwenza izakhiwo ze-peptide ngamandla ebhayoloji aphuculweyo, ukukhetha, kunye neempawu ze-pharmacokinetic. Ngokubanzi, i-ZD-Pro-OH idlala indima ebalulekileyo ekuphuculeni amasimi e-peptide chemistry, ukufunyanwa kwamayeza, kunye nophuhliso lwamayeza, ibonelela oososayensi kunye nabaphandi ngezixhobo zokuvula amandla e-peptides kunye ne-peptidomimetics okujongana nemingeni enzima yebhayoloji kunye nokuphucula ubuchule bonyango.

I-ZD-Pro-OH isetyenziswa kakhulu kwi-peptide chemistry ekwakheni ii-peptides kunye nee-peptidomimetics. Njenge-N-tert-butoxycarbonyl (Boc)-provided D-proline derivative, inceda ukufakwa kwee-D-proline residues kwii-peptide chains, inika ulungelelwaniso olulodwa lwe-stereochemical olunezicelo ezinokubakho ekuphuculeni umsebenzi webhayoloji kunye nokuzinza kwe-metabolic. Iingcali zekhemistri kunye nabaphandi basebenzisa i-ZD-Pro-OH kwi-solid-phase kunye ne-solution-phase peptide synthesis ukwazisa ii-D-proline motifs, okuvumela uyilo lwezakhiwo ezintsha ze-peptide zokunxibelelana okujoliswe kuzo kunye nee-receptors zebhayoloji kunye nee-enzymes. Ukongeza kwindima yayo kwi-peptide synthesis, i-ZD-Pro-OH ibalulekile ekuphuhlisweni kwe-peptidomimetics—ii-molecules ezenzelwe ukulinganisa iipropati kunye nemisebenzi yee-peptides ezisebenzayo. Ngokubandakanya izinto ezivela kwi-ZD-Pro-OH, izazinzulu zinokuhlola ukudalwa kwe-peptidomimetics ngeeprofayili ezahlukeneyo ze-pharmacological, zivula indlela yamayeza amatsha, ii-molecular probes, kunye nezixhobo ze-biochemical ezinezicelo zonyango kunye nophando ezinokubakho. Ngaphezu koko, i-ZD-Pro-OH isebenza njengecandelo elibalulekileyo ekuvelisweni kwamayeza kunye neyeza zonyango ezisekelwe kwi-peptide. Ubunyulu bayo obuphezulu kunye nokuthembeka kwayo kwenza ukuba ibe yinto ebalulekileyo ekuvelisweni kwee-peptides kunye ne-peptidomimetics ezenziwe ngokwezifiso kwizifundo zangaphambi kweklinikhi nezeklinikhi, zinika abaphandi ukuguquguquka kokwenza izakhiwo ze-peptide ngamandla ebhayoloji aphuculweyo, ukukhetha, kunye neempawu ze-pharmacokinetic. Ngokubanzi, i-ZD-Pro-OH idlala indima ebalulekileyo ekuphuculeni amasimi e-peptide chemistry, ukufunyanwa kwamayeza, kunye nophuhliso lwamayeza, ibonelela oososayensi kunye nabaphandi ngezixhobo zokuvula amandla e-peptides kunye ne-peptidomimetics okujongana nemingeni enzima yebhayoloji kunye nokuphucula ubuchule bonyango.