I-Z-Pro-NH2 CAS:34079-31-7

I-Z-Pro-NH2 ibaluleke kakhulu kwi-peptide chemistry ekudalweni kwee-peptides kunye nee-peptidomimetics. Njenge-N-Boc-protective L-proline amide derivative, yenza kube lula ukungeniswa kwee-proline residues kwii-peptide chains, okuvumela uyilo lwe-peptide sequences ezenziwe ngokwezifiso ezineempawu ezithile zesakhiwo kunye nokusebenza. Iingcali zekhemistri kunye nabaphandi baxhomekeke kwi-Z-Pro-NH2 kwi-solid-phase kunye ne-solution-phase peptide synthesis ukufaka ii-proline motifs, okuvumela ukuphononongwa kwezakhiwo ezintsha ze-peptide zokunxibelelana okujoliswe kuzo kunye nee-receptors zebhayoloji, ii-enzymes, kunye nezinye iinjongo ze-biomolecular. Ngaphezu koko, i-Z-Pro-NH2 ifumana ukusetyenziswa kuphuhliso lwee-peptidomimetics—ii-molecules ezenzelwe ukulinganisa iimpawu kunye nemisebenzi yee-peptides ze-bioactive. Ngokusebenzisa izinto ezivela kwi-Z-Pro-NH2, izazinzulu zinokuyila ii-peptidomimetics ngeeprofayili ezahlukeneyo ze-pharmacological, zibonelela ngamayeza anomdla, ii-molecular probes, kunye nezixhobo ze-biochemical kwizicelo zonyango kunye nophando. Ngaphezu koko, i-Z-Pro-NH2 isebenza njengecandelo elibalulekileyo ekuvelisweni kwamayeza kunye neyeza zonyango ezisekelwe kwi-peptide. Ubunyulu bayo obuphezulu kunye nokuthembeka kwayo kwenza ukuba ibe yinto ebalulekileyo ekuvelisweni kwee-peptides kunye ne-peptidomimetics ezenziwe ngokwezifiso kwizifundo zangaphambi kweklinikhi kunye nezeklinikhi, inika abaphandi ukuguquguquka kokulungisa izakhiwo ze-peptide ukuze kufezekiswe umsebenzi ophuculweyo webhayoloji, ukukhetha, kunye neempawu ze-pharmacokinetic. Ngamafutshane, i-Z-Pro-NH2 inegalelo elikhulu ekuphuculeni ikhemistri ye-peptide, ukufunyanwa kwamayeza, kunye nophuhliso lwamayeza, inika izazinzulu kunye nabaphandi iindlela zokusebenzisa amandla e-peptides kunye ne-peptidomimetics ekusombululeni imingeni enzima yebhayoloji kunye nokuqhuba ubuchule bonyango.