I-β-Nicotinamide Mononucleotide CAS:1094-61-7

I-NMN inethemba njengesongezelelo sokutya ngenxa yeenzuzo zayo ezicetywayo ezinxulumene nempilo yeselula kunye nokwaluphala. Uphando lubonisa ukuba ukongezwa kwe-NMN kunokuxhasa amanqanaba e-NAD+ kwiiseli, ezidlala indima ebalulekileyo kwimveliso yamandla eseli kunye neendlela zokulungisa i-DNA. Ngokufaka isandla ekugcinweni kwamanqanaba e-NAD+ afanelekileyo, i-NMN iphandwe ngamandla ayo okuxhasa umsebenzi we-metabolic, i-mitochondrial biogenesis, kunye nokuqina kweseli iyonke. Ngaphezu koko, ukudibana kwe-NMN kunye nokuhlanganiswa kwe-NAD+ kukhokelele kwizifundo ezihlola iimpembelelo zayo ezinokubakho ekuwohlokeni okunxulumene nobudala kunye nokuphila ixesha elide. Uphando lwangaphambi kweklinikhi lubonisa ukuba ukongezwa kwe-NMN kunokunciphisa iinkalo zokwaluphala ngokuchaphazela iindlela zeseli ezinxulumene ne-metabolism yamandla, i-circadian rhythms, kunye nempendulo yoxinzelelo lwe-oxidative, okubonelela ngemiphumo enokubakho yokwaluphala okunempilo kunye neemeko ezinxulumene nobudala. Ngaphezu koko, iingenelo ezinokubakho ze-NMN zivuse umdla ekusetyenzisweni kwayo kwicandelo lezemidlalo kunye ne-physiology yokuzilolonga. Izifundo zokuqala zibonisa ukuba ukongezwa kwe-NMN kunokuphucula ukusebenza kwe-mitochondrial kunye namandla okunyamezela kwiimodeli zezilwanyana, okubangela uphando olongezelelweyo ngendima yayo enokubakho ekukhuthazeni ukusebenza komthambo kunye nokubuyela esimeni ebantwini. Ngamafutshane, ngelixa uphando oluqhubekayo luqhubeka nokuphonononga yonke imiphumo ye-NMN, usetyenziso lwayo olunokwenzeka lubandakanya impilo yeeseli, ukwaluphala, inkxaso yemetabolism, kunye nefiziyoloji yokuzilolonga. Ngenxa yoko, i-NMN yindawo yophando lwesayensi olusebenzayo, olunefuthe elinokubakho kwimpilo yoluntu nakwimpilo-ntle kwiimeko ezahlukeneyo zefiziyoloji.