I-β-Nicotinamide Mononucleotide CAS:1094-61-7

I-β-Nicotinamide mononucleotide (NMN) isetyenziselwa ukufunda ii-motifs ezibophayo ngaphakathi kwee-aptamers ze-RNA kunye neenkqubo zokuqalisa ze-ribozyme ezibandakanya iziqwenga ze-RNA ezisebenza nge-β-nicotinamide mononucleotide (β-NMN). I-NMN yi-nucleotide ephuma kwi-ribose kunye ne-nicotinamide. I-Niacinamide (nicotinamide,) sisiphumo se-vitamin B3, ekwaziwa ngokuba yi-niacin.) Njengomlandeli we-biochemical we-NAD+, inokuba luncedo ekuthinteleni i-pellagra.
I-β-Nicotinamide mononucleotide iphakathi kwi-biosynthesis ye-nicotinamide adenine dinucleotide (NAD+). I-Nicotinamide phosphoribosyltransferase (Nampt) ivuselela ukuxinana kwe-nicotinamide nge-5-phosphoribosyl-1-pyrophosphate ukuvelisa i-β-NMN, ethi kamva iguqulwe ibe yi-NAD+ yi-β-NMN adenyltransferase. Kwi-50-100 μM, i-β-NMN isetyenziselwe ukuphucula i-NAD biosynthesis kunye nokukhutshwa kwe-insulin evuselelwe yi-glucose kwimodeli yegundane ye-Nampt+/- yesifo se-metabolic, ebonisa indima ye-Nampt kumsebenzi weseli ye-β.