I-1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

I-1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile idlala indima ebalulekileyo njengomphakathi ekuhlanganisweni kweekhompawundi ezintsonkothileyo, ezisebenzayo kunye nezicelo zamayeza ezinokubakho. Ukufakwa kwayo kwizakhelo zeemolekyuli kwenza abaphandi bakwazi ukuphonononga abaviwa abatsha bamayeza abajolise kwiindawo ezahlukeneyo zonyango ezifana ne-kinase inhibitors, ii-fluorescent probes, okanye izicelo zekhemistri yezinto. Ubukho be-pyrazole core kunye neqela le-dioxaborolane buzisa i-reactivity ethile kunye neempawu ze-pharmacophoric, okwenza ukuba ibe luncedo kuphando lwekhemistri yamayeza. Kwimizamo yokufumanisa iziyobisi, le khompawundi ingasebenza njengendawo yokuqala yokuyila abaviwa abanokubakho bamayeza, isebenzisa iimpawu zayo zesakhiwo ukulungisa umsebenzi webhayoloji kunye neempawu ze-pharmacokinetic. Ukongeza, iqela elisebenzayo le-dioxaborolane libonelela ngamathuba okufumana ngakumbi kunye nekhemistri edibanisayo, okunokukhokelela kuphuhliso lweemolekyuli ezintsha ezineempawu zebhayoloji eziphuculweyo kunye neeprofayili ze-pharmacokinetic eziphuculweyo. Ngaphezu koko, kwiindawo zemfundo nakwimizi-mveliso, abaphandi banokusebenzisa esi sakhiwo ukulungiselela iilayibrari zezinto ezahlukeneyo eziphuma kuzo kwizifundo zobudlelwane besakhiwo-umsebenzi, oku kunceda ekuchongweni kweekhompawundi zelothe ezineempembelelo ezifunwayo zebhayoloji. Indima yayo ekuqulunqweni kweekhemikhali ifikelela ekuvelisweni kwezinto ezisetyenziswayo zamayeza kunye nophuhliso lweendlela ezintsha zokwenziwa, ibonisa ukusetyenziswa kwayo ngokubanzi kuzo zonke iinkalo zesayensi. Ngokubanzi, i-1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile idlala indima ebalulekileyo ekufuneni ukufunyanwa kwamayeza amatsha kunye nophando lweekhemikhali, ibonelela ngeqonga lophuhliso lweemolekyuli ezahlukeneyo ezisebenzayo kwibhayoloji kunye nezinto ezisetyenziswayo kwimithi.