I-1,7-Dimethylindolin-2-one CAS:67358-21-8

I-1,7-Dimethylindolin-2-one idlala indima ebalulekileyo njengomlamli ekuhlanganisweni kweekhompawundi ezintsonkothileyo, ezisebenzayo kunye nezicelo zamayeza ezinokubakho. Ukufakwa kwayo kwizakhelo zeemolekyuli kwenza abaphandi bakwazi ukuphonononga abaviwa abatsha bamayeza abajolise kwiindawo zonyango ezifana neengxaki zenkqubo yemithambo-luvo ephakathi, iiarhente zokulwa namagciwane, okanye izicelo zekhemistri yezinto. Ubukho be-indolinone core buzisa i-reactivity ethile kunye neempawu ze-pharmacophoric, nto leyo eyenza ukuba ibe luncedo kuphando lwekhemistri yamayeza. Kwimizamo yokufumanisa iziyobisi, le khompawundi ingasebenza njengendawo yokuqala yokuyila abaviwa abanokubakho bamayeza, isebenzisa iimpawu zayo zesakhiwo ukuguqula umsebenzi webhayoloji kunye neempawu ze-pharmacokinetic. Ukongeza, ulwakhiwo olulodwa lwemolekyuli lubonelela ngamathuba okwahlukana, okunokukhokelela kuphuhliso lweemolekyuli ezintsha ezineempawu zebhayoloji eziphuculweyo kunye neeprofayili ze-pharmacokinetic eziphuculweyo. Ngaphezu koko, kwiindawo zemfundo nakwimizi-mveliso, abaphandi banokusebenzisa esi sakhiwo sokwakha ukulungiselela iilayibrari zezinto ezahlukeneyo eziphuma kuzo kwizifundo zobudlelwane besakhiwo-umsebenzi, okwenza kube lula ukuchongwa kweekhompawundi ze-lead ezineziphumo zebhayoloji ezifunwayo. Indima yayo ekuhlanganisweni kweekhemikhali ifikelela kwimveliso yee-intermediates zamayeza kunye nophuhliso lweendlela ezintsha zokwenziwa, ibonisa ukusetyenziswa kwayo okubanzi kuzo zonke iinkalo zesayensi. Lilonke, i-1,7-Dimethylindolin-2-one idlala indima ebalulekileyo ekufuneni ukufunyanwa kwamachiza amatsha kunye nophando lweekhemikhali, ibonelela ngeqonga lophuhliso lweemolekyuli ezahlukeneyo ezisebenzayo ngokwebhayoloji kunye nezinto ezidityanisiweyo zamayeza.