(2S,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid CAS:132622-66-3

I-(2S,4S)-1-Boc-4-aminopyrrolidine-2-carboxylic acid isebenza njengendawo ebalulekileyo ekuhlanganisweni kweekhompawundi ezintsonkothileyo, ezisebenzayo kunye nezicelo zamayeza ezinokubakho. Ubume bayo be-chiral kunye neempawu zayo ezizodwa zesakhiwo ziyibeka njengenxalenye ebalulekileyo yokwenziwa kweekhompawundi ze-enantiopure, ezibalulekileyo kuphuhliso lwamayeza. Ngokufaka esi sakhiwo kwizakhelo zeemolekyuli, abaphandi banokuhlola abaviwa abatsha bamayeza abajolise kwiindawo zonyango ezifana ne-antivirals, i-antineoplastics, okanye iingxaki zenkqubo ye-nervous system ephakathi. Kwikhemistri yamayeza, le khompawundi ingasebenza njengendawo yokuqala yokuyila abaviwa bamayeza abanokubakho, isebenzisa i-stereochemistry yayo ukuguqula umsebenzi webhayoloji kunye neempawu ze-pharmacokinetic. Ukukhuselwa kweBoc kweqela le-amino kubonelela ngolawulo phezu kokusebenza kunye nokukhetha ngexesha lotshintsho oluzayo lwe-synthetic, okuvumela ukwakhiwa kwezakhiwo ezahlukeneyo zeekhemikhali. Ngaphezu koko, kwiindawo zemfundo nakwimizi-mveliso, abaphandi banokusebenzisa esi sakhiwo sokwakha ukulungiselela iilayibrari zezinto ezahlukeneyo eziphuma kwizakhiwo kunye nomsebenzi wezifundo, kunceda ukuchongwa kweekhompawundi ze-lead ezineempembelelo zebhayoloji ezifunwayo. Indima yayo ekuhlanganisweni kweekhemikhali ifikelela kwimveliso yee-intermediates zamayeza kunye nophuhliso lweendlela ezintsha zokwenziwa, ibonisa ukusetyenziswa kwayo ngokubanzi kuzo zonke iinkalo zesayensi. Lilonke, i-(2S,4S)-1-Boc-4-aminopyrrolidine-2-carboxylic acid idlala indima ebalulekileyo ekufuneni ukufunyanwa kwamayeza amatsha kunye nokuhlanganiswa okungalinganiyo, ibonelela ngeqonga lophuhliso lweemolekyuli ezahlukeneyo ezisebenzayo ngokwebhayoloji kunye nezinto ezidityanisiweyo zamayeza.