I-4-Nitrophenyl Beta-D-glucuronide CAS:10344-94-2

I-4-Nitrophenyl Beta-D-glucuronide i-chemical compound eyenziwe ngokufaka i-molecule ye-glucose kwiqela le-4-nitrophenyl ngokusebenzisa i-glycosidic linkage.Ngokuqhelekileyo isetyenziswe njenge-substrate kwii-assays ze-enzymatic ukubona ubukho kunye nomsebenzi we-β-glucuronidase, i-enzyme echaphazelekayo kwi-metabolism yamachiza ahlukeneyo kunye ne-xenobiotics kwizilwanyana ezincelisayo.Xa i-β-glucuronidase ikhona, iqhekeza ibhondi ye-glycosidic phakathi kwe-glucose. kunye neqela le-4-nitrophenyl, elibangela ukukhululwa kwe-4-nitrophenol, enokuthi ibonwe i-spectrophotometrically kwi-400-420 nm.Le mpendulo ye-enzymatic ibonelela ngomlinganiselo wobungakanani bomsebenzi we-β-glucuronidase kwaye ihlala isetyenziswa njengesixhobo ekufumaneni iziyobisi, izifundo ze-toxicology, kunye noxilongo lweklinikhi.

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Ukufumanisa umsebenzi we-β-glucuronidase: I-4-NPBG isetyenziswa ngokuqhelekileyo njenge-substrate ye-chromogenic yokuhlola ubukho kunye nomsebenzi we-β-glucuronidase kwiisampuli ezahlukeneyo zezinto eziphilayo.I-enzyme iqhekeza ibhondi ye-glycosidic ye-4-NPBG, ivelisa i-4-nitrophenol, enokulinganiswa ngokusebenzisa i-spectrophotometry.

Izifundo zemetabolism yeziyobisi: Ekubeni i-β-glucuronidase idlala indima ebalulekileyo kwi-metabolism yamachiza kunye ne-xenobiotics, i-4-NPBG ingasetyenziselwa ukuvavanya umsebenzi wale enzyme kwizifundo zemetabolism yeziyobisi.Inceda ekuqondeni ubungakanani kunye ne-kinetics ye-glucuronidation reactions, ezibalulekileyo kucoceko lwamachiza kunye ne-bioavailability.

Izifundo ze-Toxicology: Ezinye iikhompawundi ze-toxicological zinokuthi zenziwe i-metabolized kwaye zikhutshwe ngendlela ye-glucuronide conjugates.Ngokusebenzisa i-4-NPBG njenge-substrate, abaphandi banokuhlola umsebenzi we-β-glucuronidase kwii-tissue ezahlukeneyo okanye imigca yeeseli ukuvavanya ubutyhefu obunokubakho okanye imiphumo emibi yeekhompawundi.

Ukuxilongwa kweklinikhi: Umlinganiselo we-β-glucuronidase umsebenzi usebenzisa i-4-NPBG ingasetyenziselwa kwizicwangciso zeklinikhi ukuxilonga izifo okanye iimeko ezithile.Amanqanaba angaqhelekanga okanye umsebenzi we-β-glucuronidase unokubonisa ukuphazamiseka okuthile kofuzo, ukungasebenzi kwesibindi, okanye umhlaza.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	C12H13NO9
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	10344-94-2
Ukupakisha	Incinci kwaye ininzi
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.