Candesartana Cilexetila CAS:145040-37-5

I-Candesartan cilexetil yi-prodrug ye-angiotensin II ekhethiweyo kunye ne-angiotensin II ye-receptor ye-Antagonist enamandla, i-candesartan.I-hydrolyzed ngokukhawuleza kwi-candesartan ngexesha lokufunxa kwesisu.Emva kwe-hydrolysis ye-candesartan cilexetil ukuya kwi-candesartan ngexesha lokufunxa kwesisu, i-candesartan ngokukhethayo ikhuphisana ne-angiotensin II ngokubophelela kwe-angiotensin II receptor subtype 1 AT1 kwi-vascular smooth muscle, ivimbela i-angiotensin II-mediated vasoconstriction kunye ne-inducing vasodilatation.Ukongezelela, ukuchasana kwe-AT1 kwi-adrenal gland inhibisa i-angiotensin II-ivuselelwe i-aldosterone synthesis kunye ne-secretion yi-adrenal cortex;ukunyuka kwe-sodium kunye nokunyuka kwamanzi, okulandelwa kukunciphisa umthamo we-plasma kunye noxinzelelo lwegazi.