I-Fmoc-Cys(Kodwa)-OH CAS:67436-13-9

I-Fmoc-Cys(But)-OH isebenza njengesixhobo esisisiseko ekuhlanganiseni iipeptide, ngakumbi ekwenzeni iipeptides ezine-cysteine ​​​​ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa iipeptide, ngelixa iqela le-butyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-thiol. Abaphandi basebenzisa kakhulu i-Fmoc-Cys(But)-OH ekwenziweni kweepeptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza asekelwe kwi-peptide, i-bioconjugation, kunye nokudalwa kweepeptides ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kweepeptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-cysteine ​​​​kwiindlela ze-peptide, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Cys(But)-OH ifumana uncedo ekufundeni ukugoba kweeprotein, ukwakheka kwe-disulfide bond, kunye nophuhliso lwezinto ezisekelwe kwi-peptide. Ukusetyenziswa ngobuchule kweqela lokukhusela i-butyl kwenza ukuba i-cysteine ​​reactivity isebenze ngokuchanekileyo, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelwe bona. Ngamafutshane, i-Fmoc-Cys(But)-OH imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-cysteine ​​reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi igxile kwiipeptides eziqulethe le amino acid ibalulekileyo.