I-Fmoc-Glu(OBzl)-OH CAS:123639-61-2

I-Fmoc-Glu(OBzl)-OH isebenza njengesixhobo esiguquguqukayo kwi-peptide synthesis, ngakumbi ekwenzeni iipeptides ezine-glutamic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-benzyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-Glu(OBzl)-OH ekwenzeni iipeptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila iipeptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimizamo eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-glutamic acid kwi-peptide sequences, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Glu(OBzl)-OH ifumana uncedo ekufundeni iinkqubo zeseli, ukwenziwa kwe-neuropeptide, kunye nophuhliso lwezonyango ezisekelwe kwi-peptide. Ukusetyenziswa ngobuchule kweqela lokukhusela i-benzyl kwenza kube lula ukulawula ngokuchanekileyo i-glutamic acid reactivity, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelwe bona. Ngamafutshane, i-Fmoc-Glu(OBzl)-OH imi njengesixhobo esisisiseko nesibalulekileyo kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-glutamic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ekugxileni kwiipeptides eziqulethe le amino acid ibalulekileyo.