I-Fmoc-Asp(OcHx)-OH CAS:130304-80-2

I-Fmoc-Asp(OcHx)-OH isebenza njengesixhobo esibalulekileyo ekuhlanganiseni iipeptide, ngakumbi ekwenzeni iipeptides ezine-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa iipeptide, ngelixa iqela le-octyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-Asp(OcHx)-OH ekwenziweni kweepeptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila iipeptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kweepeptides, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-aspartic acid kwizicwangciso zepeptide, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Asp(OcHx)-OH ifumana uncedo ekwenziweni kweepeptides kuphando lweproteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-octyl kwenza kube lula ukulawula ngokuchanekileyo i-aspartic acid reactivity, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olucwangcisiweyo. Ngamafutshane, i-Fmoc-Asp(OcHx)-OH imi njengesixhobo esisisiseko nesibalulekileyo kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ukugxila kwiipeptides eziqulethe le amino acid ibalulekileyo.