I-Fmoc-D-Cys(Trt)-OH CAS:167015-11-4

I-Fmoc-D-Cys(Trt)-OH isebenza njengesixhobo esisisiseko ekuhlanganiseni i-peptide, ngakumbi ekwenzeni ii-peptides eziqulethe i-D-enantiomer ye-cysteine ​​ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-trityl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-thiol. Abaphandi basebenzisa kakhulu i-Fmoc-D-Cys(Trt)-OH ekwenziweni kwee-peptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwezonyango ezisekelwe kwi-peptide, izinto eziphilayo, kunye nee-peptides ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokudibanisa i-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-D-cysteine ​​​​kwi-peptide sequences, kwandisa ububanzi bee-peptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-D-Cys(Trt)-OH ifumana uncedo kwizifundo ezinxulumene nobunjineli beprotheni, ukwakheka kwe-disulfide bond, kunye neempendulo zokudibanisa i-peptide. Ukusetyenziswa ngobuchule kweqela lokukhusela i-trityl kwenza ukuba i-D-cysteine ​​reactivity isebenze ngokuchanekileyo, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila ii-peptides ezinotshintsho olulungiselelwe bona. Ngamafutshane, i-Fmoc-D-Cys(Trt)-OH imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-D-cysteine ​​reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ingakumbi ekugxileni kwii-peptides eziqulethe le amino acid ibalulekileyo kwi-D-configuration.