Umthengisi woMvelisi weHuperzine A 1 CAS:102518-79-6

I-Huperzine A liyeza elitsha lokunyanga iingxaki zenkumbulo ezingengobungozi elinokuthintela ngempumelelo i-neurasthenia yobuchopho kubantu abaneminyaka ephakathi kunye nabantu abadala, libuyisele umsebenzi wemithambo-luvo yentloko, kwaye livuselele ii-neurotransmitters zentloko. I-Huperzine A ayinakuthintela kuphela umsebenzi we-cholinesterase, kodwa ikwaphucula umsebenzi wokuqonda kunye nokukwazi ukufunda kunye nenkumbulo ngeendlela ezahlukeneyo ze-pharmacological ezifana nokuchaphazela inkqubo yee-free radicals, ukunciphisa amanqanaba okubonakaliswa kwe-somatostatin, i-intracellular [Ca2+], umxholo we-glutamic acid kunye nokunyusa i-calmodulin (CaM) kunye ne-calmodulin messenger RNA (CaM mRNA). I-Huperzine A sisixhobo esinokwenzeka sonyango lwesifo se-Alzheimer esithintela i-alkaloid ye-AChE enqumla umqobo wegazi-ubuchopho. Inciphisa ukufa kweeseli okubangelwa yi-glutamate kwiinkcubeko eziphambili ezivela kwi-forebrain, i-hippocampus, i-cortex kunye ne-cere.