I-L-Lactate dehydrogenase CAS:9001-60-9

Isiphumo se-L-Lactate dehydrogenase (LDH) siquka indima yayo kwimetabolism yamandla eseli kunye nokubandakanyeka kwayo ekuguqulweni kwe-pyruvate ibe yi-lactate. I-LDH inceda ukugcina ulungelelwaniso lwamandla kwiiseli ngokwenza kube lula ukuguqulwa kwe-pyruvate, imveliso ephuma kwimetabolism yeglucose, ibe yi-lactate. Le nkqubo, eyaziwa ngokuba yi-anaerobic glycolysis, yenzeka xa unikezelo lwe-oxygen lunqongophele.

I-LDH ikwadlala indima ebalulekileyo ekusetyenzisweni kwakhona kwe-lactate. Ngexesha lokuzilolonga kakhulu okanye xa i-oksijini incinci, i-lactate inokuqokelelana kwizicwili. I-LDH inceda ekusetyenzisweni kwakhona kwe-lactate ngokuyiguqula ibuyele kwi-pyruvate, enokuthi emva koko isetyenziswe njengesiseko sokuveliswa kwamandla okanye iguqulwe ibe yi-glucose nge-gluconeogenesis. Le ndlela yokusetyenziswa kwakhona kwe-lactate ivumela iiseli ukuba zisebenzise ngokufanelekileyo i-lactate njengomthombo wamandla kwaye inceda ekuthinteleni ukwakheka kwe-lactate, enokuba yingozi ekusebenzeni kweseli.

I-LDH inezicelo ezininzi kwicandelo lezonyango. Enye yezona zicelo zayo ziphambili kukuchonga izifo ezithile. Amanqanaba aphezulu e-LDH egazini anokubonisa umonakalo wezicubu okanye ukubakho kwezifo ezinje ngomonakalo wesibindi, i-myocardial infarction, kunye neentlobo ezithile zomhlaza. Amanqanaba e-LDH ahlala ejongwa kwiimeko zeklinikhi ukuvavanya inkqubela phambili yesifo kunye nempendulo kunyango.