I-Linezolid CAS:165800-03-3

I-Linezolid isetyenziswa kakhulu kwizonyango zokulawula usulelo olunzima lwebhaktiriya oluneGram-positive oluchasene nezinye ii-antibiotics. Idla ngokumiselwa usulelo lwesikhumba nezicubu ezithambileyo, i-pneumonia, i-bacteremia, kunye nosulelo lwamathambo olubangelwa yi-MRSA, i-VRE, kunye nezinye ii-pathogens ezinganyangekiyo ngamayeza amaninzi. Ukukwazi kwe-Linezolid ukujolisa ezi zinto ziphilayo kunzima ukuzinyanga kwenza ukuba ibe sisixhobo esibalulekileyo sonyango ekulweni nosulelo olunzima. Kwizibhedlele, i-linezolid idla ngokusetyenziselwa unyango lwe-nosocomial sulelo kunye ne-pneumonia enxulumene nokhathalelo lwempilo ngenxa yemisebenzi yayo ebanzi kunye neprofayili yokhuseleko efanelekileyo. Ukwenziwa kwayo ngomlomo kuvumela unyango olulula lwezifo ezithile ngaphandle kwesibhedlele, kubonelela izigulane ngonyango olusebenzayo ngokuchasene nee-pathogens ezinengxaki zebhaktiriya. Ngaphezu koko, i-linezolid isetyenziswa kunyango lwesifo sephepha kunye nezinye izifo ze-mycobacterial njengenxalenye yeendlela zonyango ezidibeneyo. Indlela yayo eyahlukileyo yokusebenza kunye nokungena kakuhle kwezicubu kwenza ukuba ibe longezo oluxabisekileyo kwi-armamentarium yokunyanga isifo sephepha esinganyangekiyo ngamayeza kunye nosulelo lwe-mycobacterial olungenasifo sephepha. Kwiziko zophando, i-linezolid isetyenziswa njengomgangatho wokubhekisa kuvavanyo lokuchaphazeleka kwe-antimicrobial ukuvavanya uvakalelo lwee-isolates zebhaktiriya kule antibiotic. Ngokumisela i-minimum inhibitory concentration (MIC) ye-linezolid ngokuchasene neebhaktheriya ezithile, abaphandi banokukhokela amaqhinga afanelekileyo okunyanga kunye nokujonga iipatheni zokuxhathisa. Ngokubanzi, i-linezolid idlala indima ebalulekileyo ekulawuleni usulelo lwebhaktheriya olunzima lwe-Gram-positive, inika oogqirha ukhetho olunamandla noluthembekileyo lokunyanga iintsholongwane ezinganyangekiyo ngamayeza. Ukusebenza kwayo kakuhle, ukunyamezeleka, kunye nokuguquguquka kwenza ukuba ibe yinxalenye ebalulekileyo ekulweni nezifo ezosulelayo, ngakumbi ezo zibangelwa ziibhaktheriya ezinganyangekiyo ngamayeza amaninzi.