I-N-methyl-2,2,2-trifluoroacetamide CAS:815-06-5

I-N-Methyl-2,2,2-trifluoroacetamide (NMTFA) ibonakaliswa yisakhiwo sayo semolekyuli, equka iqela le-trifluoromethyl (-CF3) elinamathele kumqolo we-acetamide (-CONHCH3). Esi sakhiwo sinikezela uzinzo olukhulu kunye nokusabela kwi-NMTFA, okwenza ukuba ifaneleke kwiintlobo ngeentlobo zezicelo zeekhemikhali. I-NMTFA ihlala ikhona njenge-crystalline solid eneqondo lokunyibilika elimalunga nama-62°C kwaye ibonisa ukunyibilika okuhle kwi-polar organic solvents ezifana ne-acetone kunye ne-ethanol. Uzinzo lwayo phantsi kweemeko ezahlukeneyo luvumela ukusetyenziswa kwayo ngempumelelo kuphando lwelabhoratri kunye neenkqubo zoshishino. Ukusetyenziswa kwe-Organic Synthesis: I-NMTFA isebenza njenge-intermediate ebalulekileyo kwi-organic synthesis, ngakumbi ekungenisweni kwamaqela e-trifluoromethyl kwiimolekyuli ze-organic. Olu buchule lubalulekile ekuphuhliseni amayeza, ii-agrochemicals, kunye neekhemikhali ezikhethekileyo ezine-bioactive activity ephuculweyo kunye nokuzinza kweekhemikhali. I-Pharmaceutical Chemistry: Kwizicelo ze-pharmaceutical, i-NMTFA isetyenziswa njengesandulela kwi-synthesis yezithako ze-pharmaceutical ezisebenzayo (APIs) ngenxa yokukwazi kwayo ukunika iipropati ze-pharmacological ezinqwenelekayo. Idlala indima ebalulekileyo kwikhemistri yezonyango ngokuvumela ukuguqulwa kweemolekyuli zamayeza ukuphucula ukusebenza kakuhle nokunciphisa ukuthambekela kwe-metabolic. Iikhemikhali ezikhethekileyo: I-NMTFA ifumana ukusetyenziswa ekuvelisweni kweekhemikhali ezikhethekileyo ezifana nee-surfactants, ii-plasticizers, kunye ne-complex intermediates ezisetyenziswa ekuvelisweni kweekhemikhali zezolimo kunye neekhemikhali ezintle. Ukuguquguquka kwayo ekuguqulweni kweekhemikhali kuyenza ibe luncedo kwiifomyula apho kufuneka ulawulo oluchanekileyo kwisakhiwo semolekyuli kunye nokusebenza kwayo. Ukwenziwa kwe-N-Methyl-2,2,2-trifluoroacetamide kwenziwa ngokusabela kwe-trifluoroacetic acid kunye ne-methylamine. Le nkqubo ibandakanya ukujiya kwe-trifluoroacetic acid kunye ne-methylamine phantsi kweemeko ezilawulwayo ukuze kwenziwe i-NMTFA. Ukusabela kudla ngokuqhubeka xa kukho i-catalyst efanelekileyo yokunceda ukwakheka kwe-amide bond. Iindlela zokucoca ezifana ne-recrystallization okanye i-chromatography zisetyenziswa ukuze kufunyanwe i-NMTFA ngobunyulu obuphezulu obufanelekileyo kwizicelo zoshishino. Indlela ethe ngqo yokwenziwa kunye nokufumaneka kwezinto eziluhlaza kunegalelo ekusebenzeni kwayo ngexabiso elifanelekileyo kunye nokusetyenziswa ngokubanzi kuphando lwezemfundo kunye neenkqubo zoshishino. Ngamafutshane, i-N-methyl-2,2,2-trifluoroacetamide yikhompawundi eguquguqukayo enezicelo ezibalulekileyo kwi-organic synthesis, i-pharmaceutical chemistry, kunye nemveliso yeekhemikhali ezikhethekileyo. Iipropati zayo ezikhethekileyo zeekhemikhali, kubandakanya ukuzinza, ukusabela, kunye nokulula kokwenziwa, zinegalelo ekubalulekeni kwayo ekuphuculeni ubuchwepheshe kumacandelo ahlukeneyo ezoshishino kunye nezifundo zesayensi.