I-N-methyl-2,2,2-trifluoroacetamide CAS:815-06-5

I-N-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate (EMTFA) ibonakaliswa bulwakhiwo lwayo lweemolekyuli, oluquka iqela le-trifluoromethyl (-CF3) elinamathele kumqolo we-β-keto ester. Olu lwakhiwo lunika uzinzo olukhulu kunye nokusebenza kwakhona kwi-EMTFA, okwenza ifaneleke kwiintlobo ngeentlobo zezicelo zeekhemikhali. I-EMTFA ihlala ikhona njengolwelo olucacileyo, olungenambala olunendawo yokubila malunga ne-140°C kwaye lubonisa ukunyibilika okuhle kwizinyibilikisi eziqhelekileyo ze-organic ezifana ne-acetone kunye ne-ethyl acetate. Uzinzo lwayo phantsi kweemeko ezahlukeneyo luvumela ukusetyenziswa kwayo ngempumelelo kuphando lwelabhoratri kunye neenkqubo zemizi-mveliso. Ukusetyenziswa kwe-Organic Synthesis: I-EMTFA isebenza njengebhloko ebalulekileyo yokwakha kwi-organic synthesis, ngakumbi ekungenisweni kwe-trifluoromethylated motifs kwiimolekyuli ze-organic. Olu buchule lubalulekile ekuphuhliseni amayeza, ii-agrochemicals, kunye neekhemikhali ezikhethekileyo ezine-bioactive activity ephuculweyo kunye nokuzinza kweekhemikhali. I-Pharmaceutical Chemistry: Kwizicelo ze-pharmaceutical, i-EMTFA isetyenziswa njengesandulela ekuhlanganisweni kwezithako ze-pharmaceutical ezisebenzayo (APIs) ngenxa yokukwazi kwayo ukunika iipropati ze-pharmacological ezinqwenelekayo. Idlala indima ebalulekileyo kwikhemistri yezonyango ngokuvumela ukuguqulwa kweemolekyuli zamayeza ukuphucula ukusebenza kakuhle nokunciphisa ukuthambekela kwe-metabolic. Iikhemikhali ezikhethekileyo: I-EMTFA ifumana ukusetyenziswa ekuvelisweni kweekhemikhali ezikhethekileyo ezifana ne-herbicides, i-insecticide, kunye ne-complex intermediates ezisetyenziswa ekuvelisweni kwee-agrochemicals kunye neekhemikhali ezintle. Ukuguquguquka kwayo ekuguqulweni kweekhemikhali kuyenza ibe luncedo kwiifomyula apho kufuneka ulawulo oluchanekileyo kwisakhiwo se-molecular kunye nokusebenza. Ukwenziwa kwe-Ethyl 2-methyl-4,4,4-trifluoroacetoacetate kwenziwa ngenkqubo yamanyathelo amaninzi eqala nge-Claisen condensation reaction ye-ethyl trifluoroacetate ene-methyl acetate, ilandelwe yi-esterification phantsi kweemeko ezilawulwayo. Ukusabela kudla ngokuqhubeka xa kukho i-base catalyst ukuze kube lula ukwakheka kwe-β-keto ester. Iindlela zokucoca ezifana ne-distillation okanye i-recrystallization zisetyenziswa ukuze kufunyanwe i-EMTFA ngobunyulu obuphezulu obufanelekileyo kwizicelo zoshishino. Indlela ethe ngqo yokwenziwa kunye nokufumaneka kwezinto zokuqala kunegalelo ekusebenzeni kwayo ngexabiso elifanelekileyo kunye nokusetyenziswa ngokubanzi kuphando lwezemfundo kunye neenkqubo zoshishino. Ngamafutshane, i-ethyl 2-methyl-4,4,4-trifluoroacetoacetate yikhompawundi eguquguqukayo enezicelo ezibalulekileyo kwi-organic synthesis, i-pharmaceutical chemistry, kunye nemveliso yeekhemikhali ezikhethekileyo. Iipropati zayo ezikhethekileyo zeekhemikhali, kubandakanya ukuzinza, ukusabela, kunye nokulula kokwenziwa, ziyibeka njengomdlali ophambili ekuphuculeni ubuchwepheshe kumacandelo ahlukeneyo emizi-mveliso kunye nezifundo zesayensi.