Umthengisi weNatamycin/Pimaricin CAS: 7681-93-8

I-Pimaricin yi-macrocyclic tetraene eyahlulwa okokuqala kwi-Streptomyces natalensis ngo-1957. I-Pimaricin ibonisa umsebenzi obanzi wokulwa ne-fungus kwi-yeast kunye ne-filamentous fungi ngokubophelela ngokukodwa kwi-ergosterol ukuthintela ukukhula kwe-fungus. Ngokungafaniyo ne-polyenes ezinxulumene nayo, i-nystatin kunye ne-filipin, i-pimaricin ayitshintshi ukungena kwe-plasma membrane. I-Pimaricin isetyenziswa kushishino lokutya kunyango lomphezulu wetshizi njengesithinteli sokungunda. I-Natamycin sisibulali-ntsholongwane se-polyene esenziwe ngokwe-semisynthetic. I-Natamycin ayinyibiliki kakuhle emanzini kwaye ayizukungena kwi-epithelium ye-cornea engaguqukiyo. I-Natamycin yeyona arhente yokulwa ne-fungus evunyiweyo ukuba isetyenziswe esweni kwaye yeyona yeza lamehlo elifumanekayo kurhwebo lokunyanga i-fungus keratitis. I-Natamycin, eyaziwa ngokuba yi-pimaracin, iyinxalenye yosapho lwe-polyene lwee-antibiotics; (iqela lee-agent zokulwa ne-fungus ezijolise kwaye zibopha kwi-eukaryotic sterols ngakumbi i-ergosterol), kwaye yi-metabolite yesibini ye-Streptomyces natalensis.