I-R-(+)-alpha-Lipoic acid CAS:1200-22-2 Umthengisi woMvelisi

I-R-(+)-α-Lipoic acid ibonakaliswe ukuba iyandisa kakhulu i-pyruvate oxidation ngelixa isusa i-fatty acid oxidation kwi-hepatocytes zeempuku. Ezi ziphumo zenza i-R-(+)-α-Lipoic acid ibe lukhetho oluthembisayo lonyango lwesifo seswekile sohlobo lwesibini. Yi-antioxidant yebhayoloji enemisebenzi ye-prooxidant, amandla ayo okunyanga aphandwa kakhulu, umz. kunyango lwesifo se-Alzheimer. I-α-Lipoic acid isetyenzisiwe njengomgangatho wokubhekisa kuhlalutyo lwe-α-lipoic acid kwi-plasma yomntu nge-high performance liquid chromatography edityaniswe ne-electron capture detector (HPLC-ECD), kwiimatrices ezahlukeneyo zokutya kunye nezongezo zokutya yi-HPLC edityaniswe ne-coulometric electrode array detector (CEAD) kunye ne-electrospray ionization mass spectrometer (ESI-MS). Ingasetyenziswa njengomgangatho wokubhekisa kukumisela i-α-lipoic acid kumchamo womntu nge-isocratic reversed-phase HPLC nakwi-α-lipoic acid capsules yi-HPLC ene-chemiluminescence detection.