(S)-Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride CAS:15912-56-8

(S) -Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride idlala indima ebalulekileyo njengomphakathi ekuhlanganisweni kweekhompawundi ezintsonkothileyo, eziphilayo kunye nezicelo zamayeza ezinokubakho. Ukufakwa kwayo kwizakhelo zeemolekyuli kwenza abaphandi bakwazi ukuphonononga abaviwa abatsha bamayeza abajolise kwiindawo zonyango ezifana neengxaki zenkqubo yemithambo-luvo ephakathi, ii-antipsychotic agents, okanye amayeza okuthomalalisa iintlungu. Ulwakhiwo olukhethekileyo lwale khompawundi luzisa i-reactivity ethile kunye neempawu ze-pharmacophoric, okwenza ukuba ibe luncedo kuphando lwekhemistri yezonyango. Kwimizamo yokufumanisa iziyobisi, le khompawundi ingasebenza njengendawo yokuqala yokuyila abaviwa abanokubakho bamayeza, isebenzisa iimpawu zayo zesakhiwo ukuguqula umsebenzi webhayoloji kunye neempawu ze-pharmacokinetic. Ukongeza, uhlobo lwe-chiral lwemolekyuli lunokuchaphazela kakhulu ukusebenzisana kwayo neethagethi zebhayoloji, olunokuthi luchaphazele iimpawu zayo ze-pharmacological kwaye luphucule ukusetyenziswa kwayo kuphuhliso lwamayeza. Ngaphezu koko, kwiindawo zemfundo nakwimizi-mveliso, abaphandi banokusebenzisa esi sakhiwo ukulungiselela iilayibrari zezinto ezahlukeneyo eziphuma kuzo kwizifundo zobudlelwane besakhiwo-umsebenzi, okwenza kube lula ukuchongwa kweekhompawundi ze-lead ezineempembelelo zebhayoloji ezifunwayo. Indima yayo ekuqulunqweni kweekhemikhali ifikelela kwimveliso yee-intermediates zamayeza kunye nophuhliso lweendlela ezintsha zokwenziwa, ibonisa ukusetyenziswa kwayo okubanzi kuzo zonke iinkalo zesayensi. Lilonke, i-(S)-Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride idlala indima ebalulekileyo ekufumaneni amayeza amatsha kunye nophando lweekhemikhali, ibonelela ngeqonga lophuhliso lweemolekyuli ezahlukeneyo ezisebenzayo ngokwebhayoloji kunye nezinto ezidityanisiweyo zamayeza.