Umthengisi we-Spironolactone CAS: 52-01-7

I-Spironolactone (Aldactone) yikhompawundi eyaphuhliswa okokuqala njenge-mineralocorticoid antagonist kwaye isetyenziswa njenge-diuretic kunye ne-antihypertensive agent. Nangona kunjalo, xa uthatha iidosi eziphezulu, i-spironolactone ibopha kwi-androgen receptor. Kwimisebenzi yeklinikhi, yi-androgen antagonist ebuthathaka esetyenziselwa ukunyanga i-hirsutism kwabasetyhini ngokuthintela ukubopha kwe-testosterone kwi-androgen receptors kwi-follicles yeenwele. Ukusetyenziswa kwe-spironolactone kwabasetyhini kunyango lwe-hirsutism okanye i-pattern baldness yamadoda kunokubangela amanqanaba aphezulu e-potassium egazini; la manqanaba kufuneka ahlolwe kwinyanga e-1 emva kokuqala iyeza. I-Spironolactone (Aldactone) inxulumene ngokwesakhiwo ne-aldosterone kwaye isebenza njengomthinteli okhuphisanayo ukuthintela ukubopha kwe-aldosterone kwiproteni yayo ethile yokubopha iiseli.