I-Teduglutide CAS: 197922-42-2 uMboneleli woMvelisi

I-Teduglutide (eyaziwa ngokuba yi-ALX-0600) yi-analogue ye-GLP-2 apho i-glycine ithathelwe indawo ye-alanine kwindawo ye-2 ukusuka kwi-N-terminus, ngaloo ndlela inikezela ukuchasana nokuthotywa kwe-DPP-4.I-Teduglutide inobudlelwane obubophezelayo obufanayo, i-agonist potency, kunye nokusebenza kwe-agonist njenge-GLP-2 kwiimvavanyo kunye ne-rat GLP-2 receptor.Ulawulo lwe-teduglutide kwiigundane lunike ukwanda okukhulu kwesisindo samathumbu amancinci kunye nokunyuka kokuphakama kwe-intestinal villi.I-Teduglutide yalungiswa nge-soli-phase peptide synthesis.

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Isicelo kunye nesiphumo

I-Teduglutide yi-hormone ye-peptide esetyenziselwa ukunyanga izigulana zabantwana kunye nokusebenza kwexesha elide.Kuye kwaboniswa ukuba iyasebenza kunyango lwezifo ezizimele kunye nesifo sesibindi.Yi-analogue yexesha elide ye-glucagon-like peptide 1 (GLP-1).Ichiza libonakaliswe ukuba linozinzo oluphezulu lweekhemikhali, oku kuthetha ukuba ayiphuli ngokulula.I-Teduglutide ijojowe emzimbeni kwaye ithathwe ngamaseli, apho yenza i-receptors isebenze kumphezulu weeseli.Oku kusebenze kukhokelela ekwandeni kwemveliso ye-glucose ngesibindi kunye nokuphucula uvakalelo lwe-insulin kwizicubu ze-peripheral ezifana nezihlunu, amafutha kunye nesibindi.Ikwanyusa izinga lokubetha kwentliziyo kunye noxinzelelo lwegazi.

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Ukupakishwa kweMveliso:

Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C164H252N44O55S
Isivavanyi	99%
Imbonakalo	Mhlophe ukuya kumgubo oMhlophe
Inombolo yeCAS.	197922-42-2
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.