I-Trt-Gly-OH CAS:5893-05-0

I-Bz-His-OMe idlala indima ebalulekileyo ekwakhiweni kwe-peptide, isebenza njengebhloko ebalulekileyo yokwakha ii-peptide ezineempawu ezithile zesakhiwo kunye nokusebenza. Iqela elikhusela i-benzyl liqinisekisa ukuba intsalela ye-histidine ihlala ingatshintshi ngexesha leenkqubo zokwenziwa kwe-peptide, okuvumela ukuhlanganiswa kwe-peptide ngokuchanekileyo nangokulawulwayo. Ukongeza, ubukho beqela le-methyl ester buchaphazela ukusabela kwamakhemikhali kunye nokusebenzisana kwe-hydrophobic kwe-peptide, okwenza ibe luncedo ekuyileni ii-peptides ezinokwandiswa kokungena kwe-membrane okanye izakhono ezithile zokujolisa. Ekuphuhlisweni kwamayeza, le khompawundi ingasetyenziselwa ukwenza amayeza asekelwe kwi-peptide anozinzo oluphuculweyo kunye nokufumaneka kwezinto eziphilayo, okunokukhokelela ekusebenzeni ngcono konyango. Ukongeza kwindima yayo ekwakhiweni kwe-peptide, i-Bz-His-OMe ifumana isicelo kuphando lwe-proteomics kunye ne-biochemical, apho inokusetyenziswa khona ukufunda ukusebenzisana kwe-protein-protein, ukuphanda imisebenzi ye-enzyme, kunye nokuphonononga utshintsho oluxhomekeke kwi-pH kwiiproteni. Ulwakhiwo lwayo olulungiselelweyo luvumela abaphandi ukuba baphonononge ubunzima beenkqubo zeseli kunye neendlela zesifo, okufaka isandla ekuphuhliseni ukuqonda impilo kunye ne-pathology. Ukuguquguquka kunye nokuhambelana kwale compound neemeko ezahlukeneyo zovavanyo kwenza ukuba ibe yinxalenye ebalulekileyo yokutyhila ubunzima beenkqubo zebhayoloji kunye nokuphuhlisa iindlela zokungenelela ezijolise kwiimeko ezahlukeneyo zonyango. Ngamafutshane, i-Bz-His-OMe imele isixhobo esibalulekileyo kubaphandi kwi-peptide synthesis, uphuhliso lwamayeza, kunye nezifundo ze-biochemical, enika amandla okulungisa iipeptides ezineempawu ezithile kunye nokusombulula iindlela ezisisiseko zeenkqubo zebhayoloji, ngaloo ndlela inegalelo ekuphuhliseni amayeza kunye ne-biotechnology.