Umthengisi woMvelisi weDuloxetine HCL CAS:136434-34-9

I-Duloxetine HCL luhlobo lwetyuwa ye-duloxetine, iyeza lokulwa noxinzelelo. Yaphuhliswa ngempumelelo yi-Eli Lilly Company. Isiphumo sayo se-pharmacological sifana ne-duloxetine. I-Duloxetine hydrochloride luhlobo olutsha lwe-5 hydroxy trptamine (5-HT) kunye ne-norepinephrine reuptake, kwaye ngaloo ndlela inesiphumo sokulwa noxinzelelo, ngelixa ikwanomphumo wokuthintela intlungu ephakathi. Uphawu lwayo lwe-pharmacological kukukwazi ukuthintela ukuphinda kuthathwe kwe-neuronal pre-synaptic membrane kwi-5-hydroxy trptamine kunye ne-norepinephrine kodwa endaweni yoko inesiphumo esiphantsi sokuthintela ukuphinda kuthathwe kwe-dopamine. I-Duloxetine hydrochloride iboniswe kwixinzelelo kwaye iyasebenza ekunyangeni uxinzelelo lwe-endogenous kunye nolwe-endogenous kunye nemvakalelo yentlungu ehambelana nokudakumba. Inedosi yonyango ye-60mg/d~120mg/d kunye nokhuseleko oluhle kunye neempendulo ezimbalwa ezimbi kunye neempendulo eziqhelekileyo ezimbi ezifana nokucaphuka, umlomo owomileyo, ukuqhina, ukungatyi kakuhle, ukudinwa, ukozela, kunye nokubila okukhulu. Enye into ebonakalisa intlungu ebangelwa yi-diabetes neuropathy.