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I-Adenosine CAS: 58-61-7
I-Adenosine yi-nucleoside eyenziwe yi-adenine kunye ne-ribose, edlala indima ebalulekileyo kwi-metabolism yeseli. Isebenza njengesiseko sokwakha i-adenosine triphosphate (ATP), imali yamandla ephambili kwiinkqubo zebhayoloji. Ngaphandle kwemisebenzi yayo enxulumene namandla, i-adenosine ibandakanyeka kwiinkqubo ezahlukeneyo ze-physiological, kubandakanya ukudluliselwa kwe-neurotransmission, i-vasodilation, kunye nokulawula umjikelo wokulala nokuvuka. Isebenza kwii-receptors ezithile, ichaphazela izinga lentliziyo kunye nokuhamba kwegazi. Ngokwezonyango, i-adenosine isetyenziswa kunyango, ngakumbi kunyango lwe-arrhythmias ethile yentliziyo. Iindima zayo ezininzi zigxininisa ukubaluleka kwe-adenosine kwimpilo nakwizifo.
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I-Uridine 5-monophosphate, ityuwa ye-disodium CAS:3387-36-8
I-Uridine 5-monophosphate, ityuwa ye-disodium (UMP) yi-nucleotide edlala indima ebalulekileyo kwi-metabolism yeseli kunye nokwenziwa kwe-RNA. Iquka i-pyrimidine base uracil, iswekile ye-ribose, kunye neqela le-phosphate, i-UMP ibalulekile kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukwenziwa kwee-nucleic acids kunye nokulawulwa kweendlela ze-metabolic. Uhlobo lwetyuwa ye-disodium luphucula ukunyibilika kwayo kunye nokuzinza kwizisombululo zamanzi, okwenza ukuba ifaneleke kuphando lwelabhoratri kunye nokusetyenziswa kwezonyango. I-UMP ifumene ingqalelo ngenxa yeempawu zayo zokukhusela i-neuroprotective kunye nokuphucula ingqondo, kunye nendima yayo ekukhuthazeni impilo yeseli iyonke.
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I-Cytidine 5′- (i-disodium phosphate) I-CAS:6757-06-8
I-Cytidine 5′- (disodium phosphate) yi-nucleotide derivative eyenziwe yi-pyrimidine base cytosine, iswekile ye-ribose, kunye neqela le-phosphate. Le khompawundi idlala indima ebalulekileyo kwiinkqubo ezahlukeneyo ze-biochemical, kubandakanya ukwenziwa kwe-RNA, iindlela zokulawula, kunye nokuhanjiswa kwemiqondiso yeseli. Uhlobo lwetyuwa ye-disodium luphucula ukunyibilika kwayo kunye nokuzinza kwiimeko zomzimba, okwenza ukuba ifaneleke kuphando lwelabhoratri kunye nezicelo zonyango ezinokubakho. I-Cytidine 5′- (disodium phosphate) ifumene umdla wokubandakanyeka kwayo kwi-metabolism ye-nucleic acid kunye neenzuzo zayo ezinokubakho ekuphuculeni umsebenzi wokuqonda kunye nokuxhasa impilo yeseli.
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I-5-Azacytidine CAS:320-67-2
I-5-Azacytidine yi-cytidine analogue ye-cytidine eyenziweyo ene-atom ye-nitrogen kwindawo ye-5 yeringi ye-pyrimidine, ithatha indawo ye-atom yekhabhoni. Olu tshintsho lunika iipropati ezikhethekileyo ze-pharmacological, nto leyo eyenza ukuba ibe yi-compound ebalulekileyo kwi-molecular biology kunye nonyango lomhlaza. Njenge-DNA methyltransferase inhibitor enamandla, i-5-azacytidine inokuvuselela ii-genes ezithuliweyo ngokutshintsha iipateni ze-DNA methylation, ngaloo ndlela ichaphazela ukubonakaliswa kwe-gene. Ekuqaleni yenzelwe ukunyanga i-hematologic moccansies, i-5-azacytidine ifumene ingqalelo kwizicelo zayo ezinokubakho kunyango lwe-epigenetic, amayeza okuvuselela, kunye nophando olujolise kwizifo ezahlukeneyo ezibonakaliswa kukulawulwa kwe-gene okungaqhelekanga.
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I-2′-Fluoro-2′-deoxyuridine CAS:784-71-4
I-2′-Fluoro-2′-deoxyuridine (FdU) yi-nucleoside analog ye-deoxyuridine, apho i-athomu ye-hydrogen kwindawo ye-2′ yeswekile ye-ribose ithathelwa indawo yi-athomu ye-fluorine. Olu tshintsho luphucula uzinzo kunye nokusebenza kwe-bioactivity ye-compound, okwenza ibe luncedo kuphando lwe-biochemical kunye nokusetyenziswa kwezonyango. I-FdU yaziwa kakhulu ngendima yayo njenge-arhente ye-antiviral kunye ne-anticancer, njengoko inokuphazamisa ukwenziwa kwe-DNA kwaye ithintele ukuphindaphinda kweentsholongwane ezithile kunye neeseli zomhlaza. Iimpawu zayo ezikhethekileyo zenza ukuba ibe sisixhobo esibalulekileyo kuphuhliso lwezonyango ezijoliswe kuzo kunye nezifundo zebhayoloji yemolekyuli.
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![I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
I-4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one yi-analog ye-nucleoside eyinkimbinkimbi enesiseko se-pyrimidine esiqhotyoshelwe kwiswekile ye-ribose eguquliweyo. Ukubakho kwe-athomu ye-fluorine kunye namaqela e-hydroxyl kwisakhiwo sayo kuphucula iipropati zayo ze-biochemical, okwenza ukuba ibe ngumviwa onomdla wophando lwe-antiviral kunye ne-anticancer. Le khompawundi inezicelo ezinokubakho kwikhemistri yamayeza, ngakumbi njengearhente yonyango ejolise ekuqulunqweni kwe-nucleic acid kunye neendlela ze-metabolic kwizinto eziphilayo ezibangela izifo. Iimpawu zayo ezizodwa zesakhiwo zivumela ukusebenzisana okungcono neethagethi zebhayoloji ezibandakanyeka kwi-metabolism ye-DNA kunye ne-RNA.
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I-1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
I-1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose luhlobo lwe-ribose oluguqulwe ngokweekhemikhali, oluquka amaqela amathathu e-benzoyloxy anamathele kwizikhundla ze-1, 3, kunye ne-5 zesakhiwo se-ribofuranose. Olu tshintsho luphucula ukunyibilika kwayo kunye nokuzinza, okwenza ukuba ibe luncedo kwiindlela ezahlukeneyo zokwenziwa kwi-organic chemistry kunye ne-biochemistry. Njenge-derivative ekhuselweyo ye-ribose, isebenza njengomphakathi ekuhlanganisweni kwee-nucleosides kunye nee-nucleotides, izinto ezibalulekileyo ze-RNA kunye ne-DNA. Iimpawu zayo ezikhethekileyo zenza i-1,3,5-tri-O-benzoyl-alpha-D-ribofuranose ibe luncedo kubaphandi abafuna ukuphuhlisa ii-arhente zonyango ezintsha kunye nezixhobo kwi-nucleotide chemistry.
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I-2′-O-methyluridine CAS:2140-76-3
I-2′-O-Methyluridine yi-nucleoside yendalo apho iqela le-methyl linamathele kwi-athomu yeoksijini yesikhundla se-2′ seswekile ye-ribose kwi-uridine. Olu tshintsho luphucula uzinzo kunye nokusebenza kwee-molecule ze-RNA, nto leyo eyenza ukuba ibe yinxalenye ebalulekileyo kwiinkqubo ezahlukeneyo zebhayoloji. I-2′-O-Methyluridine idlala indima ebalulekileyo kwisakhiwo kunye nomsebenzi wee-ribonucleic acids (ii-RNA), kubandakanya i-messenger RNA (mRNA) kunye ne-transfer RNA (tRNA). Ubukho bayo bunokuchaphazela uzinzo lwe-RNA, ukusebenza kakuhle koguqulelo, kunye nokusebenzisana neeproteni kunye nezinye ii-nucleic acids, nto leyo eyenza ukuba ibe yinto ebalulekileyo kuphononongo lwe-molecular biology kunye nokusetyenziswa konyango.
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i-adenosine 5′-monophosphate sodium* evela kwimvubelo i-CAS:4578-31-8
I-Adenosine 5′-monophosphate sodium (AMP) yi-nucleotide ephuma kwi-adenosine edlala indima ebalulekileyo kwi-metabolism yeseli. I-AMP ibalulekile kwiinkqubo ezahlukeneyo zebhayoloji, kubandakanya ukudluliselwa kwamandla, ukuhanjiswa kwesignali, kunye nokwandulela ukwenziwa kwe-ATP kunye nezinye ii-nucleotides. Uhlobo lwetyuwa yesodiyam ye-AMP lunokufumaneka kwi-yeast, etyebileyo kwii-nucleotides ngenxa yeendlela zayo ezisebenzayo ze-metabolism. Le compound isetyenziswa kakhulu kwi-biochemistry nakwi-pharmacology njenge-reagent ye-biochemical, isongezo sokutya, kunye nesongezo sokutya, ngenxa yeenzuzo zayo zempilo kunye nokusetyenziswa kwayo ekukhuthazeni imetabolism yamandla.
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I-2′-Deoxycytidine CAS:951-77-9
I-2′-Deoxycytidine yi-nucleoside eyenziwe yiswekile ye-deoxyribose kunye ne-cytosine, eyahlulwa kukungabikho kweqela le-hydroxyl kwindawo ye-2′ ye-ribose. Olu tshintsho lwenza ukuba ibe yinxalenye ebalulekileyo ye-DNA, apho idibana khona ne-guanine ngexesha lokudibanisa isiseko. I-2′-Deoxycytidine idlala indima ebalulekileyo kwi-metabolism yeseli kunye nokuhlanganiswa kwe-DNA, isebenza njengebhloko yokwakha i-deoxycytidine triphosphate (dCTP), ebalulekileyo ekuphindaphindweni nasekulungisweni kwe-DNA. Ukongeza, le nucleoside ineempembelelo ezibalulekileyo kuphando lwebhayoloji ye-molecular, unyango lomhlaza, kunye namaqhinga okulwa neentsholongwane, igxininisa ukubaluleka kwayo kuphando olusisiseko kunye nokusetyenziswa kweklinikhi.
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I-2,2′-cyclouridine CAS:3736-77-4
I-2,2′-Cyclouridine yi-bicyclic nucleoside derivative ye-uridine, ebonakaliswa kukwenziwa kwesakhiwo esijikelezayo esikhethekileyo esibandakanya izikhundla ze-2′ kunye ne-2” ze-ribose moiety. Olu tshintsho lwesakhiwo lunika iipropati ezahlukeneyo ze-biochemical ezichaphazela uzinzo lwayo kunye nomsebenzi webhayoloji. I-2,2′-Cyclouridine ifumene umdla kwi-biology yamakhemikhali kunye ne-chemistry yamayeza ngenxa yezicelo zayo ezinokubakho njenge-arhente ye-antiviral kunye nophando lwe-RNA. Amandla ayo okuguqula ukusebenzisana kwe-nucleic acid kuyenza ibe sisixhobo esibalulekileyo sokufunda ubudlelwane besakhiwo se-RNA nomsebenzi, okunokukhokelela ekuqhubekeni kwezicwangciso zonyango ezijolise kwiintsholongwane kunye nezifo zemfuza.
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I-2-Aminoadenosine CAS:2096-10-8
I-2-Aminoadenosine yi-nucleoside derivative yendalo ye-adenosine, eyahlula ngokubakho kweqela le-amino kwindawo ye-2 yeswekile ye-ribose. Olu tshintsho lutshintsha kakhulu iipropati kunye nemisebenzi yayo ye-biochemical, okwenza ibe yimolekyuli ebalulekileyo kwiinkqubo ezahlukeneyo ze-physiological. I-2-Aminoadenosine ibandakanyeka kwimiqondiso yeseli, imetabolism, kunye neendlela zokulawula, kubandakanya ezo zinxulumene ne-energy homeostasis kunye ne-neurotransmission. Ukusetyenziswa kwayo okunokwenzeka konyango kubandakanya iinkalo ezininzi, kubandakanya i-neurobiology kunye ne-cardiology, apho inokuchaphazela iimpendulo zeseli kuxinzelelo kunye nokwenzakala. Njengoko uphando luqhubeka, i-2-aminoadenosine inesithembiso sokuphuhlisa iikhompawundi ezintsha ze-bioactive kunye neearhente zonyango.
