I-FmFmoc-Asp-OBut CAS:129460-09-9

I-Fmoc-Asp-OBut isebenza njengesixhobo esibalulekileyo ekuhlanganiseni iipeptide, ngakumbi ekwenzeni iipeptides ezine-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa iipeptide, ngelixa iqela le-O-butyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-Asp-OBut ekwenziweni kweepeptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila iipeptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kweepeptides, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-aspartic acid kwizicwangciso zepeptide, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Asp-OBut ifumana uncedo ekwenziweni kweepeptides kuphando lweproteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-O-butyl kwenza ukuba kusetyenziswe ngokuchanekileyo i-aspartic acid reactivity, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelweyo. Ngamafutshane, i-Fmoc-Asp-OBut imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ukugxila kwiipeptides eziqulethe le amino acid ibalulekileyo.