I-Fmoc-Arg(Tos)-OH CAS:83792-47-6

I-Fmoc-Arg(Tos)-OH idlala indima ebalulekileyo ekuhlanganisweni kwe-peptide, ingakumbi xa kufuneka ukhuseleko oluchanekileyo lwe-guanidine nitrogen kwi-arginine. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-tosyl kwi-guanidine nitrogen libonelela ngomaleko owongezelelweyo wokhuseleko. Abaphandi basebenzisa i-Fmoc-Arg(Tos)-OH ekudibaniseni ii-peptides ngotshintsho oluthile lwe-guanidine, oluchaphazela imisebenzi yazo yebhayoloji. Indlela yokukhusela kabini ivumela ukuphathwa okulawulwayo kwe-reactivity ye-guanidine, okwenza le compound ibe luncedo ekuyileni ii-peptides kwizifundo ze-antimicrobial, i-bioconjugation, kunye ne-medical chemistry. Ukuhambelana kwe-Fmoc-Arg(Tos)-OH neendlela ezisemgangathweni zokwenziwa kwe-peptide, kubandakanya i-solid-phase peptide synthesis (SPPS), kuphucula ukusetyenziswa kwayo. Le compound ifumana isicelo ekwakheni ii-peptides zovavanyo lwebhayoloji, ukufunyanwa kwamayeza, kunye nophuhliso lwezinto ezisekwe kwi-peptide. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-arginine kunye ne-guanidine eguquliweyo, okufaka isandla kwiintlobo ngeentlobo zeepeptides ezinokwenziwa. Ngamafutshane, i-Fmoc-Arg(Tos)-OH imi njengesixhobo esikhethekileyo nesinokuguquguquka kwikhemistri yepeptide, inika amandla abaphandi ukuba baphonononge kwaye batshintshe i-reactivity ye-guanidine kwiintlobo ngeentlobo zezicelo zesayensi kunye nezonyango.