I-Fmoc-D-Asn(Trt)-OH CAS:180570-71-2

I-Fmoc-D-Asn(Trt)-OH ibalulekile ekuqulunqweni kwe-peptide, ingakumbi ekwenzeni ii-peptides eziqulethe i-D-enantiomer ye-asparagine ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-trityl longeza umaleko owongezelelweyo wokhuseleko. Abaphandi basebenzisa i-Fmoc-D-Asn(Trt)-OH kakhulu ekwakhiweni kwee-peptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila ii-peptides ezisebenzayo ezine-stereochemical configurations ezithile. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-D-asparagine kwizicwangciso ze-peptide, kwandisa uluhlu lwee-peptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-D-Asn(Trt)-OH ifumana uncedo ekwakhiweni kwee-peptides kuphando lwe-proteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-trityl kwenza ukuba i-D-asparagine reactivity isebenze ngokuchanekileyo, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila ii-peptides ezinotshintsho olulungiselelwe bona. Ngamafutshane, i-Fmoc-D-Asn(Trt)-OH imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-D-asparagine reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ekugxileni kwii-peptides eziqulethe ii-D-amino acids.