I-Fmoc-Asp(OBut)-OH CAS:71989-14-5

I-Fmoc-Asp(OBut)-OH sisixhobo esiguquguqukayo kwi-peptide synthesis, ngakumbi ekwenzeni iipeptides ezine-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-O-butyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-Asp(OBut)-OH kwi-synthesizing peptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila iipeptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimizamo eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-aspartic acid kwi-peptide sequences, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Asp(OBut)-OH ifumana uncedo kwi-synthesizing peptides kuphando lwe-proteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-O-butyl kwenza ukuba kusetyenziswe ngokuchanekileyo i-aspartic acid reactivity, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelweyo. Ngamafutshane, i-Fmoc-Asp(OBut)-OH imi njengesixhobo esisisiseko nesibalulekileyo kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ukugxila kwiipeptides eziqulethe le amino acid ibalulekileyo.