I-Fmoc-Asp(OBut)-OSu CAS:78553-23-8

I-Fmoc-Asp(OBut)-OSu isebenza njengesixhobo esiguquguqukayo kwi-peptide synthesis, ngakumbi ekwenzeni iipeptides ezine-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-O-butyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Ukusebenza kwe-OSu ester kwenza kube lula ukwakheka kwe-amide bond esebenzayo neyokukhethayo ngexesha lokusabela kwe-peptide coupling. Abaphandi basebenzisa kakhulu i-Fmoc-Asp(OBut)-OSu ekwenzeni iipeptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila iipeptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimizamo eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-aspartic acid kwi-peptide sequences, kwandisa uluhlu lweepeptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Asp(OBut)-OSu ifumana uncedo kwi-synthesizing peptides kuphando lwe-proteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-O-butyl kwenza kube lula ukulawula i-aspartic acid reactivity, kwaye iqela le-OSu ester lenza kube lula ukuhlanganiswa kwee-peptides kunye nokubhalwa kwee-peptides. Ngamafutshane, i-Fmoc-Asp(OBut)-OSu imi njengesixhobo esisisiseko nesibalulekileyo kwi-peptide chemistry, inika amandla abaphandi ukuba baphonononge kwaye batshintshe i-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ukugxila kwii-peptides ezinokuphucula ukusebenza ngeqela le-OSu ester.