I-Fmoc-Asp(OBzl)-OH CAS:86060-84-6

I-Fmoc-Asp(OBzl)-OH idlala indima ebalulekileyo ekuhlanganisweni kwe-peptide, ingakumbi ekwenzeni ii-peptides ezine-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-benzyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-Asp(OBzl)-OH ekwakhiweni kwee-peptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila ii-peptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-aspartic acid kwizicwangciso ze-peptide, kwandisa uluhlu lwee-peptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-Asp(OBzl)-OH ifumana uncedo ekwakhiweni kwee-peptides kuphando lwe-proteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-benzyl kwenza ukuba kusetyenziswe ngokuchanekileyo i-aspartic acid reactivity, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelweyo. Ngamafutshane, i-Fmoc-Asp(OBzl)-OH imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, inika abaphandi amandla okuphonononga nokuguqula i-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ukugxila kwiipeptides eziqulethe le amino acid ibalulekileyo.