I-Fmoc-D-Asp(OBut)-OH CAS:112883-39-3

I-Fmoc-D-Asp(OBut)-OH isebenza njengesakhi esibalulekileyo ekuhlanganisweni kwe-peptide, ngakumbi ekwenzeni ii-peptides eziqulethe i-D-enantiomer ye-aspartic acid ngokuchanekileyo. Iqela elikhuselayo le-Fmoc likhusela iqela le-amino, liqinisekisa iimpendulo ezikhethiweyo ngexesha lokudibanisa i-peptide, ngelixa iqela le-O-butyl longeza umaleko owongezelelweyo wokhuseleko kwiqela le-carboxyl. Abaphandi basebenzisa kakhulu i-Fmoc-D-Asp(OBut)-OH ekwakhiweni kwee-peptides kwizicelo ezahlukeneyo, kubandakanya uphuhliso lwamayeza, izinto eziphilayo, kunye nokuyila ii-peptides ezisebenzayo ezineempawu ezithile zesakhiwo. Ukuhambelana kwayo neendlela eziqhelekileyo zokwenziwa kwe-peptide, kuzo zombini izicwangciso zesigaba esiqinileyo kunye nesigaba sesisombululo, kuphucula ukuguquguquka kwayo kwimisebenzi eyahlukeneyo yophando. Ukususwa okulawulwayo kwamaqela akhuselayo kuvumela ukufakwa kwe-D-aspartic acid kwiindlela ze-peptide, kwandisa uluhlu lwee-peptides ezinokwenziwa. Ngaphezu koko, i-Fmoc-D-Asp(OBut)-OH ifumana uncedo ekwakhiweni kwee-peptides kuphando lwe-proteomics kunye nokufunda iinkqubo zeseli. Ukusetyenziswa ngobuchule kweqela lokukhusela i-O-butyl kwenza ukuba i-D-aspartic acid reactivity isebenze ngokuchanekileyo, nto leyo enika abaphandi isixhobo esibalulekileyo sokuyila iipeptides ezinotshintsho olulungiselelwe bona. Ngamafutshane, i-Fmoc-D-Asp(OBut)-OH imi njengesixhobo esiguquguqukayo nesingenamsebenzi kwi-peptide chemistry, esinika abaphandi amandla okuphonononga nokuguqula i-D-aspartic acid reactivity kwiindidi ezahlukeneyo zezicelo zesayensi, ngakumbi ekugxileni kwiipeptides eziqulethe le amino acid ibalulekileyo.