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I-N-Acetyl-D-Glucosamine CAS: 7512-17-6 Umthengisi woMvelisi
N-I-Acetyl-D-Glucosamine yi-N-acetyl derivative ye-glucosamine. Ngokwekhemikhali yi-amide phakathi kwe-glucosamine kunye ne-acetic acid. Inxalenye enye ye-N-acetlyglucosamine edibene ne-serine okanye i-threonine residues kwiiproteni zenyukliya kunye ne-cytoplasmic -O-GlcNAc, lutshintsho lweproteni olufumaneka rhoqo emva kokuguqulwa. Iiproteni eziguqulweyo ze-O-GlcNAc zibandakanyeka ekuboneni imeko yesondlo sendawo ejikelezileyo yeseli kunye nokulungisa umsebenzi weeproteni zeseli ngokufanelekileyo. I-O-GlcNAc ilawula iimpendulo zeseli kwiihomoni ezifana ne-insulin, iqalisa impendulo yokukhusela kuxinzelelo, iguqula amandla eseli okukhula nokwahlukana, kwaye ilawula ukubhalwa kwezakhi zofuzo. Kubantu, ikhona eluswini, kwi-cartilage nakwimithambo yegazi njengenxalenye ye-hyaluronic acid, nakwizicubu zethambo, kwi-cornea nakwi-aorta njengenxalenye ye-keratan sulfate.
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Umthengisi weCreatine Pyruvate CAS: 55965-97-4
I-Creatine Pyruvate yi-compound equka i-Creatine kunye ne-pyruvic acid kwaye isetyenziswa ngabakhi bomzimba njengesongezelelo ukuze bafumane iziphumo ze-ergogenic kwaye iyanyibilika ngokupheleleyo emanzini. Kwimo yayo ye-compound i-Creatine Pyruvate inyibilika ngokuphindwe kalishumi kunakwimo yazo nganye. Izifundo zeklinikhi zibonise ukuba i-Pyruvate inciphisa amafutha omzimba ngaphandle kokuchaphazela iproteni yemisipha, into ebalulekileyo ekufezekiseni ubunzima bemisipha engenamafutha. Izongezo ze-Creatine Pyruvate zinkxaso efanelekileyo yesondlo kubadlali abafuna ukwandisa ukusebenza kwemisipha kunye nokunyamezela kwiinkqubo zokuzilolonga ezinamandla.
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IVitamin A Palmitat CAS: 79-81-2 Umthengisi woMvelisi
I-Retinyl palmitate ikwiqela leekhompawundi ezibizwa ngokuba zii-retinoids, ezifana neekhemikhali ne-vitamin A. Ibonisa impembelelo eluncedo ekuboneni, eluswini nakwimisebenzi yomzimba yokuzikhusela, ithintela ukwanda kweeseli kwaye ithintele umhlaza. Yindlela ebalulekileyo yokutya kunye nekhompawundi yonyango. I-All-trans-retinyl palmitate yi-all-trans-retinyl ester efunyenwe ngokufunxwa okusemthethweni kweqela le-carboxy le-palmitic (hexadecanoic acid) kunye neqela le-hydroxy le-all-trans-retinol. Isetyenziswa kwiimveliso zokuthambisa ukunyanga iingxaki ezahlukeneyo zesikhumba ezifana ne-acne, ukuguga kwesikhumba, imibimbi, amabala amnyama, kwaye ikwakhusela kwi-psoriasis. Inendima njenge-Escherichia coli metabolite, i-metabolite ye-xenobiotic yomntu kunye ne-antioxidant. Yi-retinyl palmitate kunye ne-all-trans-retinyl ester. Inxulumene ngokusebenza ne-all-trans-retinol.
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Umthengisi weBenfotiamine CAS: 22457-89-2
I-S-Benzoylthiamine I-O-monophosphate (iBenfotiamine) sisiphumo se-S-acyl thiamine esihlala emanzini. Sisivithamini esinyibilikayo kwi-lipid. I-Benfotiamine ineringi ye-thiazole. I-Benfotiamine inokufumaneka kakhulu kwi-bioavailability kune-thiamine.
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I-Collagen Hydrolyzed CAS: 92113-31-0 Umthengisi woMvelisi
I-Hydrolyzed collagen ikwabizwa ngokuba yi-hydrolyzed collagen. I-Hydrolyzed collagen luhlobo olutsha lwemveliso ye-collagen, eveliswa kwi-collagen okanye izixhobo ezityebileyo ze-collagen. Ukongeza kwi-amino acid composition ye-collagen (malunga ne-30% yee-amino acid residues iyonke yi-glycine), ikwanayo ne-15-30% yee-amino acid ezimbini ezingafumaneki rhoqo kwezinye iiproteni, i-proline kunye ne-4-hydroxyproline Ukongeza kwi-asidi), ikwanayo neempawu zobunzima obuncinci beemolekyuli, kwaye ulwakhiwo luquka ikakhulu iipeptides ezincinci ezinobunzima beemolekyuli ezingaphantsi kwama-3000.
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I-CAS yendalo yeVithamin E: 59-02-9 Umthengisi woMvelisi
Ioyile yeVitamin E yivithamini enyibilikayo emafutheni, eyaziwa ngokuba yitocopherol. Yenye yezona antioxidants zibalulekileyo. Yizinyibilikisi zendalo ezinyibilikayo emafutheni ezifana ne-ethanol, kwaye ayinyibiliki emanzini, ishushu, izinzile yiasidi, i-base-labile. Ibuthathaka kwioksijini kodwa ayichaphazeleki bubushushu. Kwaye umsebenzi wevithamini E wawuphantsi kakhulu ekutshiseni. I-α-Tocopherol yenziwe kwi-γ-tocopherol ngesenzo se-enzyme γ-tocopherol methyltransferase. Yeyona ndlela iphambili yeVitamin E kwiplasma yomntu. Ifumaneka kwioyile yembewu yelanga.
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I-Curcumin (i-turmeric) 95% CAS: 458-37-7 Umthengisi woMvelisi
I-Curcumin yeyona pigment iphambili emthubi kwi-turmeric nakwi-curry kwaye inemisebenzi ye-antioxidant, anti-inflammatory, kunye ne-antitumor. Ithintela ukuveliswa kwe-nitric oxide (NO) (IC50 = 6 μM) kwaye inciphisa umsebenzi we-nitric oxide synthase (iNOS) kwiiseli ze-RAW 264.7 ezivuselelwe yi-LPS. I-Curcumin ithintela ukukhululwa kwe-histamine kunye ne-cytokines ezivuthayo i-TNF-α, IL-1β, IL-6, kunye ne-IL-8 kwiiseli ze-HMC-1 mast. Kwi-vivo, i-curcumin yehlisa amanqanaba e-histamine kunye ne-TNF-α kwi-serum, ithintela utshintsho lwe-histopathological kwi-mucosa yempumlo, kwaye inciphisa inani lokuthimla kunye nokuhlikihla kwimpumlo kwimodeli yegundane ye-ovalbumin-induced rhinitis.
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IVithamin B1 (iThiamine Hydrochloride) I-CAS: 67-03-8 Umthengisi woMvelisi
I-Thiamine Hydrochloride luhlobo lwetyuwa ye-hydrochloride ye-thiamine (i-vitamin B1), i-vitamin ebalulekileyo kwi-metabolism ye-aerobic, ukukhula kweeseli, ukudluliselwa kwe-nerve impulses kunye nokwenziwa kwe-acetylcholine. I-Vitamin B1 inceda ukuthintela iingxaki ezahlukeneyo zempilo kubandakanya nomonakalo wentliziyo.
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Umthengisi woMvelisi weHydroxycobalamin HCL CAS:78091-12-0
I-Hydroxycobalamin (ohcbl, okanye i-B12a) luhlobo lwendalo lwe-vitamin B12, okanye olunye lweeklasi ze-vitamin B12. Lilungu eliphambili leqela le-cobalamine. Uninzi lweebhaktheriya ezivelisa iivithamini zivelisa i-vitamin B12 ngendlela ye-hydroxycobalamin. I-Hydroxycobalamin ibomvu obumnyama. I-Vitamin B12 emzimbeni womntu ayifumaneki ngendlela ye-hydroxycobalamin. Nangona kunjalo, ebantwini, i-hydroxycobalamin iguqulwa ngokulula ibe luhlobo lwe-coenzyme oluluncedo lwe-vitamin B12. Imveliso ye-hydroxycobalamin yezonyango yinaliti yayo engenazintsholongwane, esetyenziselwa ukunyanga ukungabikho kweevithamini kunye netyhefu ye-cyanide (kuba iyahambelana nee-ion ze-cyanide).
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I-Collagen II CAS: 9064-67-9 Umthengisi woMvelisi
I-Collagen yeyona nto iphambili kwi-extracellular matrix eneprotheyini eninzi yesakhiwo se-fibrous kuzo zonke izinto eziphezulu. Ifumaneka kakhulu kwizicubu ezine-fibrous ezifana nolusu, i-ligament kunye ne-tendon ngendlela ye-fibrils ende kwaye ikwafumaneka kakhulu kwi-cornea, imithambo yegazi, amathambo, i-cartilage, i-intervertebral disc kunye namathumbu. Ezi zezona protein zininzi kwizilwanyana ezanyisayo eziquka ngaphezulu kwe-30% yeeprotheyini zizonke emzimbeni wesilwanyana.
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I-Nicotinamide Riboside (Chloride) CAS:23111-00-4 Umthengisi woMvelisi
I-Nicotinamide Riboside Chloride luhlobo lwetyuwa ye-chloride ye-nicotinamide riboside (NR). I-NR luhlobo olutsha lwe-pyridine-nucleoside ye-vitamin B3 esebenza njengomanduleli we-nicotinamide adenine dinucleotide (NAD) okanye i-NAD+. I-Nicotinamide riboside chloride luhlobo lwekristale lwe-Nicotinamide riboside (NR) chloride. I-Nicotinamide riboside chloride yonyusa amanqanaba e-NAD[+] kwaye isebenze i-SIRT1 kunye ne-SIRT3, igqibela ngokuphucula i-oxidative metabolism kunye nokukhuselwa kwi-high fat-induced diet-impairments. I-Nicotinamide riboside chloride isetyenziswa kwi-diet supplements.
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Ityuwa ye-D-Fructose 1,6-Disphosphate Trisodium CAS:38099-82-0
I-Fructose-1,6-biphosphate (F1,6P) yi-glycolytic intermediate eveliswa kukudluliselwa kwe-phosphate ukusuka kwi-ATP ukuya kwi-fructose-6-phosphate yi-enzyme phosphofructokinase. I-Fructose-1,6-biphosphate, kunye ne-fructose-2,6-biphosphate, ilawula umsebenzi we-phosphofructokinase-1 (PFK-1), inyathelo elithintela izinga kwi-glycolysis. Ngexesha le-glycolysis, i-aldolase yahlula i-Fructose-1,6-biphosphate ibe yi-dihydroxacetone phosphate (DHAP) kunye ne-glyceraldehyde phosphate. I-Fructose-1,6-biphosphate ikwayi-allosteric activator ye-M2 isoform ye-Pyruvate Kinase (PK-M2), uhlobo oluphambili lwe-pyruvate kinase kwiiseli zomhlaza.
