I-Letrozole yinxalenye yesizukulwana esitsha se-aromatase inhibitors ekhethiweyo kakhulu kwaye i-artificially synthesized benzotriazole derivative.I-Letrozole inqanda i-aromatase ekunciphiseni amanqanaba e-estrogen, ngaloo ndlela ikhusela i-estrogen ekukhuthazeni ukukhula kwe-tumor.Umsebenzi wayo we-vivo unamandla ngamaxesha angama-150-250 kunalowo wesizukulwana sokuqala i-aromatase inhibitor i-Amarante.Njengoko ikhetha kakhulu, ayiyi kuchaphazela i-glucocorticoid, i-mineralocorticoid kunye nemisebenzi ye-thyroid;nakwiidosi eziphezulu, aziyi kuba nemiphumo yokuthintela kwi-adrenal corticosteroid secretion, inika isalathisi esiphezulu sonyango.