I-Olmesartan Medoxomil CAS: 144689-63-4 uMboneleli woMvelisi

Olmesartan Medoxomil, yinto entsha ekhethiweyo kunye nokhuphiswano lwe-nonpeptide angiotensin II uhlobo lwe-1 ye-receptor antagonist kwaye ivimbela ngokunamandla iimpendulo ze-Ang.ll-induced pressor.Ichiza ngokukhuphisanayo lithintele ukubophelela kwe- [125I1] -Zonke kwi-AT1 receptors kwiinwebu ze-adrenal cortical, kodwa azizange zibe nefuthe ekubopheni i-AT2 receptors kwiinwebu ze-cerebellar yenkomo.I-Olmesartan medoxomil ikwabonakaliswe ukuba yehlisa uxinzelelo lwegazi ngokubonakalayo ngakumbi kune-losartan kunye ne-ACE inhibitor captopril kwaye ngempumelelo njenge-pbloker atenolol.

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I-Olmesartan medoxomil sisichasi se-angiotensin II receptor esetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu.I-Olmesartan isebenza ngokuthintela ukubophelela kwe-angiotensin II kwi-AT1 receptors kwi-vascular muscle.Ngokuthintela ukubopha kunokuba kuhlanganiswe i-angiotensin II, i-olmesartan inqanda ingxelo engalunganga yokulawula kwi-renin secretion.I-Olmesartan medoxomil sisiyobisi se-pro-esterified kwi-metabolite esebenzayo, i-olmesartan.I-Olmesartan ineendlela ezimbini zokuphelisa, malunga ne-60% ekhutshwe sisibindi kunye nentsalela yintso.Kwiimeko zokungasebenzi kakuhle kwe-renal okanye hepatic, enye indlela yokukhupha ilindle inokubuyekeza lowo usengozini.

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Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C29H30N6O6
Isivavanyi	99%
Imbonakalo	Imhlophe ukuya kwi-beige powder
Inombolo yeCAS.	144689-63-4
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.