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I-N, N-Bis (2-hydroxyethyl) -2-aminoethanesulfonic acid ityuwa yesodium CAS: 66992-27-6
I-N,N-Bis(2-hydroxyethyl) -2-aminoethanesulfonic acid ityuwa yesodium, ekwaziwa ngokuba yi-HEPES ityuwa yesodium, yikhompawundi yekhemikhali esetyenziswa ngokuqhelekileyo njenge-agent ephazamisayo ye-pH kwiilebhu zebhayoloji kunye neekhemikhali.Inceda ukugcina uluhlu lwe-pH oluzinzile, okwenza lube lulungele izicelo ezifana nenkcubeko yeeseli, i-enzyme assays, izifundo zeprotheyini, i-electrophoresis, kunye ne-pharmaceutical formulations.I-HEPES ityuwa yesodium iqinisekisa iimeko ezifanelekileyo kwiinkqubo zebhayoloji kwaye iphakamisa ukuchaneka nokuthembeka kweziphumo zovavanyo.
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2′-(4-METHYLUMBELLIFERYL)-ALPHA-DN-ACETYLNEURAMINIC ACID SODIUM ISAT CAS:76204-02-9
I-2'- (4-Methylumbelliferyl) -alpha-DN-acetylneuraminic ityuwa ye-sodium ityuwa yikhemikhali esetyenziswa ngokuqhelekileyo kwiimvavanyo zokuxilonga kunye nophando.Yinto ephuma kwi-fluorescent ebhalwe nge-sialic acid, udidi lwemolekyuli yecarbohydrate efumaneka kumphezulu weeseli.
Le khompawundi isetyenziswa njenge-substrate yee-enzymes ezibizwa ngokuba yi-neuraminidases, esebenza ukususa iintsalela ze-asilic acid kwi-glycoproteins kunye ne-glycolipids.Xa ezi enzyme zisebenza kwi-2'- (4-Methylumbelliferyl) -alpha-DN-acetylneuraminic acid ityuwa yesodium, ikhupha imveliso ye-fluorescent eyaziwa ngokuba yi-4-methylumbelliferon.
I-fluorescence eyenziwa yi-compound inokulinganiswa kunye nokulinganisa, inika ulwazi malunga nomsebenzi we-neuraminidase enzymes.Oku kuluncedo ngakumbi kwisifundo sezifo ezahlukeneyo kunye neemeko ezinxulumene ne-aberrant sialic acid metabolism.
Ikhompawundi ikwasetyenziselwa iinjongo zokuxilonga, ezifana nokufumanisa usulelo lwentsholongwane olubandakanya umsebenzi we-neuraminidase.Kolu vavanyo, ikhompawundi isetyenziselwa ukuchonga ubukho beentlobo ezithile zentsholongwane okanye ukuvavanya ukusebenza kwe-neuraminidase inhibitors kunyango lwe-antiviral.
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I-TAPSO CAS: 68399-81-5 Ixabiso lomvelisi
I-TAPSO (3- [N-tris(hydroxymethyl)methyl]amino] -2-hydroxypropanesulfonic acid) sisithinteli se-zwitterionic esisetyenziswa ngokuqhelekileyo kuphando lwebhayoloji kunye ne-biochemical.Yi-arhente esebenzayo yokuthintela ene-pKa ekufutshane ne-pH yefiziyoloji, iyenza ifaneleke ukugcina i-pH ezinzileyo kwimifuniselo yebhayoloji.I-TAPSO isoloko isetyenziselwa ukuhlanjululwa kweeprotheyini, iimvavanyo ze-enzyme, inkcubeko yeeseli, kunye nokusetyenziswa kwe-electrophoresis.Ukunyibilika kwayo okuphezulu kwamanzi kunye nokuphazamiseka okuphantsi kweenkqubo zebhayoloji kwenza kube lukhetho oludumileyo kuluntu lwesayensi.I-TAPSO yaziwa ngempembelelo yayo encinci kumsebenzi we-enzyme kwaye ihlala isetyenziswa njengenye indlela kwezinye ii-agent eziphazamisayo ezifana ne-Tris okanye i-phosphate buffers.
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N-Acetyl-L-cysteine CAS: 616-91-1
I-N-Acetyl-L-cysteine (NAC) yindlela elungisiweyo ye-amino acid cysteine.Inika umthombo we-cysteine kwaye inokuguqulwa ngokulula kwi-tripeptide glutathione, i-antioxidant enamandla emzimbeni.I-NAC yaziwa ngepropathi yayo ye-antioxidant kunye ne-mucolytic, iyenza ibe luncedo kwizicelo ezahlukeneyo zempilo.
Njenge-antioxidant, i-NAC inceda ukukhusela iiseli kumonakalo obangelwa yi-radicals yamahhala, iintlobo ze-oksijini ezisebenzayo, kunye ne-toxins.Ikwaxhasa i-glutathione synthesis, edlala indima ebalulekileyo kwiinkqubo zokukhupha umzimba kunye nokugcina amajoni omzimba asempilweni.
I-NAC ifundwe ngezibonelelo zayo ezinokuthi zibekho kwimpilo yokuphefumla, ngakumbi kubantu abaneemeko ezinjenge-bronchitis engapheliyo, i-COPD, kunye ne-cystic fibrosis.Idla ngokusetyenziswa njenge-expectorant ukunceda ukubhitya kunye nokukhulula i-mucus, okwenza kube lula ukucima iindlela zomoya.
Ngaphezu koko, i-NAC ibonise isithembiso ekuxhaseni impilo yesibindi ngokuncedisa ekususweni kwezinto ezinobuthi, ezifana ne-acetaminophen, i-painkiller yentlungu eqhelekileyo.Isenokuba neziphumo ezikhuselayo kumonakalo wesibindi obangelwa kukusetyenziswa kotywala.
Ukongeza kwiipropathi zayo ze-antioxidant kunye nenkxaso yokuphefumla, i-NAC iye yaphononongwa ngezibonelelo zayo ezinokubakho kwimpilo yengqondo.Olunye uphando lubonisa ukuba lunokuba nefuthe elihle kwiingxaki zengqondo, ezifana nokudakumba kunye nokuphazamiseka okunyanzelekileyo (OCD).
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IIPIPE CAS: 5625-37-6 Ixabiso lomvelisi
I-PIPES (i-piperazine-1,4-bisethanesulfonic acid) yi-zwitterionic buffering ikhompawundi edla ngokusetyenziswa kuphando lwebhayoloji kunye ne-biochemical.Sisithinteli se-pH esisebenzayo esinomthamo ophezulu wokugcina iimeko ze-pH ezizinzileyo kuluhlu lwe-pH lwe-6.1 ukuya kwi-7.5.I-PIPES inokuphazamiseka okuncinci kunye ne-biomolecules kwaye ifanelekile kwiimvavanyo ezixhomekeke kwiqondo lokushisa.Ihlala isetyenziswa kwiindlela ze-gel electrophoresis kunye nokuqulunqwa kwamachiza njenge-agent agent.Ngokubanzi, i-PIPES yikhompawundi eguquguqukayo kwaye isetyenziswa ngokubanzi kwiseto ezahlukeneyo zovavanyo.
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2′,6′-DiMethylcarbonylphenyl-10-sulfopropylacridiniumM-9-carboxylate 4′-NHS Ester CAS:194357-64-7
I-2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridinium-9-carboxylate 4'-NHS ester yikhemikhali yekhemikhali kunye nesakhiwo esiyinkimbinkimbi se-molecular.Iqulethe iqela le-sulfopropylacridinium kunye neqela elisebenzayo le-carboxylate ester.Ubukho be-ester moiety bubonisa ukuba i-reactive kwaye ingasetyenziselwa njengeleyibhile okanye i-agent yokuguqula i-biomolecules.
Iqela le-compound ye-sulfopropylacridinium licebisa ukuba inokuba nezicelo ezinokuthi zisetyenziswe kwiimvavanyo ezisekelwe kwi-fluorescence, apho inokuthi isetyenziswe njengeprobe ye-fluorescent okanye idayi yokukhangela kunye nokuhlalutya i-biomolecules.Isenokuba nokubaluleka kwizifundo zeenkqubo zeselula, ezifana ne-intracellular calcium signaling.
Ukufakwa kweqela le-ester le-NHS libonisa ukuba linokusabela ngee-amine eziphambili, ezifana nezo zifunyenwe kwiiprotheni okanye i-peptides, ukwenza iibhondi ze-amide ezizinzile.Oku kuphinda kusebenze kwenza kube luncedo kwizicelo ze-bioconjugation, apho ingasetyenziselwa ukubhala okanye ukuguqula i-biomolecules kunye nezinye iiamolekyu ezisebenzayo, ezifana ne-fluorophores okanye iithegi.
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I-5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide CAS:4264-82-8
I-5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide yikhompawundi esetyenziswa kwizifundo ezahlukeneyo ze-biochemical, ngokukodwa ukufumanisa kunye nokubonwa komsebenzi we-enzyme.I-substrate enokuthi ifakwe i-hydrolyzed ngama-enzymes athile, okukhokelela ekukhululweni kwemveliso enemibala okanye ye-fluorescent.
Le khompawundi isetyenziswa ngokuqhelekileyo kwiimvavanyo zokubona ubukho kunye nomsebenzi wee-enzyme ezifana ne-beta-galactosidase kunye ne-beta-glucuronidase.Ezi enzymes ziqhekeza amaqela e-acetyl kunye ne-glucosaminide ukusuka kwi-substrate, ekhokelela ekubunjweni kwechromophore eluhlaza okwesibhakabhaka okanye eluhlaza.
Isakhiwo esiyingqayizivele se-5-Bromo-4-chloro-3-indolyl-N-acetyl-beta-D-glucosaminide ivumela ukufumanisa lula kunye nokulinganisa umsebenzi we-enzyme.Ukusetyenziswa kwayo kwiindlela ezahlukeneyo zokulinga, kubandakanywa i-histochemistry, i-immunohistochemistry, kunye ne-cell-based assays, ibe negalelo ekuqondeni ngcono imisebenzi ye-enzyme.
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Ityuwa yetyuwa yesodium CAS: 139-41-3 Ixabiso lomvelisi
I-N, N-Bis (2-hydroxyethyl) ityuwa ye-sodium ye-glycine yikhompawundi yemichiza esetyenziswa njenge-agent ephazamisayo kwizicelo ezahlukeneyo ze-biochemical kunye ne-biophysical.Inceda ukugcina izinga le-pH elizinzile kwiimeko zovavanyo, okwenza kube luncedo kwizifundo ze-enzyme, uphando lweprotheyini, inkcubeko yeseli, kunye neendlela zokuqhawula zaseNtshona.
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I-Spinosad CAS: 131929-60-7 uMboneleli woMvelisi
I-Spinosad liqela le-5 i-nicotinic acetylcholine receptor agonist, ebangela ukunyanzeliswa kwemisipha yokuzikhethela kunye nokungcangcazela okwesibini kwi-motor neuron activation.Ukuba sesichengeni ixesha elide kubangela ukukhubazeka nokufa kweentakumba.Ukufa kwentakumba kuqala kwimizuzu engama-30 yokudosa kwaye kwiiyure ezi-4 kugqityiwe.I-Spinosad ayidibanisi neendawo zokubophelela kwezinye ii-insecticidal agents (GABA-ergic okanye i-nicotinic).
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I-Rotenone CAS: 83-79-4 uMboneleli woMvelisi
I-Rotenone sisisu kunye netyhefu yokudibana kwi-arthropods.Isenzo sayo esikhawulezileyo sokubetha sibangelwa kukuncipha kokufumaneka kwe-nicotinamide adenine dinucleotide ukuze isebenze njenge-cofactor kwiindlela ezahlukeneyo ze-biochemical kubandakanya umjikelo we-Krebs, ngaloo ndlela inqanda i-enzayim yokuphefumla ye-mitochondrial.
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I-Diazinon CAS: 333-41-5 uMboneleli woMvelisi
I-Diazinon ifumaneka ngendlela yolwelo olungenambala okanye oluntsundu.Ayinyibiliki kancinci emanzini kodwa inyibilika kakhulu kwi-petroleum ether, etywaleni, nakwibenzene.I-Diazinon isetyenziselwa ukulawula iintlobo ngeentlobo zezolimo kunye nezinambuzane zasemakhaya.Ezi ziquka izinambuzane ezitshabalalisayo emhlabeni, kwizityalo zokuhombisa, iziqhamo, imifuno, kunye nezityalo kunye nezinambuzane zasemakhaya ezifana neempukane, iintakumba, kunye namaphela.
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I-Avermectin CAS: 71751-41-2 uMboneleli woMvelisi
I-Abamectin (i-Avermectin) yi-agent ye-nerve enetyhefu.Indlela yayo ijolise kwi-GABAA receptor ye-insect neuron synapse okanye i-neuromuscular synapse, ephazamisa ukuhanjiswa kolwazi lwe-nerve endings, oko kukuthi, ukuvuselela i-nerve endings ukukhulula i-neurotransmitter inhibitor γ-aminobutyric acid (GA-BA), ebangela ukuvulwa ngokubanzi kwe-nerve. I-GABA-gated chloride channel ene-chloride channel-activating effect.
