Leflunomide CAS:75706-12-6 uMboneleli woMvelisi oMfanisiweyo

I-Leflunomide CAS: 75706-12-6 uMboneleli woMvelisi

I-Leflunomide sisiyobisi se-antirheumatic esifumaneka ngomlomo kwaye yasungulwa njenge-Arava e-US kunyango lwe-rheumatoid arthritis (RA);liyeza lokuqala kunye nekuphela kweyeza eliya kuboniswa ukuba licothise umonakalo odibeneyo wesakhiwo se-RA, ngoko ke ukujongana nesidingo sonyango esingafezekiyo.I-Leflunomide yi-pro-drug ekhawulezayo kwaye iphantse isetyenziswe ngokupheleleyo kwi-metabolized (isiqingatha sobomi,

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I-Leflunomide ayisebenzi, kodwa i-teriflunomide inqanda i-pyrimidine de novo synthesis kwiidosi eziphantsi zonyango ngokuthintela i-dihydroorotate dehydrogenase (i-enzyme yokugqiba isantya sokuhlanganiswa kwe-UMP), ukunciphisa i-DNA kunye ne-RNA synthesis, kunye nokubamba umjikelo wokwanda kweeseli kunye nokuveliswa kwee-antibodies.Ukunciphisa i-dihydroorotate kwi-orotate kwenzeka ngaxeshanye kunye nokunciphisa i-cofactor yayo, ubiquinone (coenzyme Q).Ukuvinjelwa kwe-dihydroorotate dehydrogenase nge-teriflunomide kubonisa i-kinetics engakhuphisaniyo kunye nokungakhuphisani.Ukulawulwa kwe-leflunomide kwizigulane ezine-rheumatoid arthritis kubangela ukususwa okuqhubekayo kweeseli ze-B kunye nokulawulwa kwenkqubo yokuzivikela komzimba.

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Ukupakishwa kweMveliso:

Iinkcukacha ezongezelelweyo:

Ukuqamba	I-C12H9F3N2O2
Isivavanyi	99%
Imbonakalo	Umgubo omhlophe
Inombolo yeCAS.	75706-12-6
Ukupakisha	25KG
Beka ubomi kwishelufa	iminyaka eyi-2
Ugcino	Gcina kwindawo epholileyo neyomileyo
Isiqinisekiso	ISO.